Human GDF7 adenoviral particles

Growth differentiation factor 7 (GDF7), also known as bone morphogenetic protein 12 (BMP12), is a member of the transforming growth factor beta (TGF-β) superfamily. This secreted signaling protein plays a crucial role in embryonic development, tissue homeostasis, and regeneration. GDF7 is particularly known for its involvement in the differentiation and maintenance of connective tissues, including tendons, ligaments, and cartilage. Studies have shown that it promotes the formation of tendon-like structures and enhances the repair of musculoskeletal injuries. The GDF7 gene encodes a precursor protein that is proteolytically cleaved to release the mature, biologically active dimer. Due to its potent osteogenic and chondrogenic properties, GDF7 has attracted much attention in the fields of regenerative medicine, orthopedic research, and gene therapy applications. Human GDF7 adenoviral particles are engineered viral vectors designed to efficiently deliver the GDF7 gene to target cells or tissues. These particles are based on adenovirus, a non-enveloped DNA virus known for its high transduction efficiency, broad tropism, and ability to infect both dividing and non-dividing cells. Adenoviral vectors carrying the GDF7 gene enable stable transient expression of the protein, making them a valuable tool for research in tissue engineering, wound healing, and musculoskeletal repair. These particles are often produced using advanced packaging cell lines to ensure high titer and purity, while their safety features, such as replication deficiency, minimize risk in experimental settings. Researchers have used these particles to study the therapeutic potential of GDF7 in preclinical models, including tendon injury, osteoarthritis, and spinal cord regeneration.