Human ABL1 Knockdown Cell Line-HeLa

Name: Human ABL1 Knockdown Cell Line-HeLa
SKU: CSC-RK0033
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0033

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RK0033
Target Gene	ABL1
Abbr	HeLa-HuABL1 Knockdown
Alias	ABL1, ABL, c-ABL, v-abl, bcr/abl
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ABL1 c-abl oncogene 1, non-receptor tyrosine kinase [ Homo sapiens ]
Gene Symbol	ABL1
Synonyms	ABL; JTK7; p150; c-ABL; v-abl; bcr/abl
Gene Description	v-abl Abelson murine leukemia viral oncogene homolog 1
GeneID	25
Uni ProtID	P00519
mRNA Refseq	NM_007313.2
Protein Refseq	NP_009297.2
Chromosome Location	9q34.1
Function	ATP binding; DNA binding; SH3 domain binding; actin monomer binding; magnesium ion binding; manganese ion binding; mitogen-activated protein kinase binding; nicotinate-nucleotide adenylyltransferase activity; non-membrane spanning protein tyrosine kinase activity; proline-rich region binding; protein C-terminus binding; protein binding; protein tyrosine kinase activity;
Pathway	Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; CDO in myogenesis, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem;
MIM	189980

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The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

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