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THBD

Official Full Name
thrombomodulin
Organism
Homo sapiens
GeneID
7056
Background
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
Synonyms
TM; THRM; AHUS6; BDCA3; CD141; BDCA-3; THPH12;

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