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Serpina1a

Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 1A
Organism
Mus musculus
GeneID
20700
Background
Predicted to enable identical protein binding activity; protease binding activity; and serine-type endopeptidase inhibitor activity. Acts upstream of or within protein N-linked glycosylation; response to cytokine; and response to peptide hormone. Located in extracellular region. Is expressed in gut; liver lobe; and renal calyx. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Serpina1a; PI1; Aat2; Dom1; Aat-2; Spi1-1; Spi1-3;

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