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PYGL


Official Full Name
glycogen phosphorylase L
Organism
Homo sapiens
Gene ID
5836
Background
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]
Synonyms
GSD6

Cat.No. Product Name Price
SHH387440 shRNA set against Human PYGL (NM_002863.4) Inquiry
SHH387444 shRNA set against Mouse PYGL (NM_133198.2) Inquiry
SHR156090 shRNA set against Rat Pygl(NM_022268.1) Inquiry
SHW004905 shRNA set against Chicken PYGL (NM_204392) Inquiry
SHW007757 shRNA set against Danio rerio PYGL (NM_001008538) Inquiry
Cat.No. Product Name Price
CDFH015658 Human PYGL cDNA Clone(NM_001163940.1) Inquiry
CDFR011951 Rat Pygl cDNA Clone(NM_022268.1) Inquiry
MiUTR1R-06233 PYGL miRNA 3'UTR clone Inquiry
MiUTR3H-13027 PYGL miRNA 3'UTR clone Inquiry
MiUTR3H-13028 PYGL miRNA 3'UTR clone Inquiry
CDCB166380 Chicken PYGL ORF Clone (NM_204392) Inquiry
CDCB169232 Danio rerio PYGL ORF Clone (NM_001008538) Inquiry
CDCB189349 Rabbit PYGL ORF clone (XM_002718303.2) Inquiry
CDCH070336 human PYGL ORF clone (NM_001163940.1) Inquiry
CDCR264784 Mouse Pygl ORF Clone(NM_133198.2) Inquiry
CDCR378954 Rat Pygl ORF Clone(NM_022268.1) Inquiry
CDCS408734 Human PYGL ORF Clone (BC082229) Inquiry
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