PABPC5

Official Full Name

poly(A) binding protein cytoplasmic 5

Organism

Homo sapiens

GeneID

140886

Background

This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010]

Synonyms

PABP5;

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Detailed Information

PABPC5 gene is mapped to X-specific sub-interval in the Xq21.3/Yp11.2 Homology block of the human sex chromosomes

The isolation and characterization of poly(A)-binding protein gene, PABPC5, which is located in the X-specific 13d-sY43 sub-interval of the Xq21.3/Yp11.2 homology block has been reported. Determination of its structure and pattern, or refinement of the physical mapping of the region on the X and corresponding segment on the Y, have shown that there is highly conservation of PABPC5 in primates and rodents but without a conserved homologous counterpart on the human Y chromosome.

The novel gene PABPC5 has been described with the characterization of derivation from X-specific sub-interval and belonging to the poly(A)-binding protein gene family. Its genomic structure has coverage of 4061 bp of an uninterrupted open reading frame (ORF) and a 5' UTR spanning across two exons and associated with a CpG island. In addition to this, 4 RNA recognition motif domains were contained within the potential 382-amino-acid protein. PABPC5 has 73% nucleotide identity with PABPC4 over 1802 bp of the ORF and share60 identity and 73% similarity with human PABPC4, as well as Xenopus PABPC1. Expression of PABPC5 can be seen in fetal brain and in a range of adult tissues by the RT-PCR assays.

Regulation on vasculogenic mimicry of glioma by PABPC5/HCG15/ZNF331 feedback loop initiated STAU1-mediated mRNA decay

PABPC5 (poly(A) binding protein cytoplasmic 5), located on chromosome Xq21.3/Yp11.2 as a member of the cytosolic poly(A) binding protein family, can binds to the protein at the 3' end of the poly(A) rail of most eukaryotic mRNAs, and it was found to be involved in DNA and RNA metabolism in mitochondria. Due to its location on translocation breakpoint DX214 and association with premature ovarian failure in ovarian disease, high expression of PABPC5 has been confirmed to be closely related to poor prognosis of ovarian cancer patients. And in accorded with the concept of vasculogenic mimicry (VM) was firstly proposed by Maniotis in the study of melanoma, where can see vascular channels independent from endothelial cells generated tumor cells, anti-VM can be listed as a new strategy for glioma treatment, for which vasculogenic mimicry (VM) work as one of the blood supply methods, is the most common primary malignancy in the brain. Although active treatment, such as surgery, radiation therapy, and chemotherapy can improve the symptoms of glioma, there are still a high recurrence rate and low average median survival time. And vascular mimicry-related genes and signal transduction resorted pathways, such as feedback loop of PABPC5/HCG15/ZNF331 in glioma cell lines and role of them in regulating glioma VM will provide new molecular mechanisms for glioma development.

Pabpc5 Figure 1. PABPC5, HCG15, and ZNF331 involved new molecular mechanisms for glioma development. (Fangkun Jing, et al. 2020)

References:

Blanco P, Sargent C A, Boucher C A, et al. A novel poly (A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21. 3/Yp11. 2 homology block of the human sex chromosomes. Genomics, 2001, 74(1): 1-11.
An T, Deng L, Wang Y, et al. The prognostic impacts of PABPC1 expression on gastric cancer patients. Future Oncology, 2021, 17(33): 4471-4479.

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