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PTGDR

Official Full Name
prostaglandin D2 receptor (DP)
Background
The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+.Knockout studies in mice suggest that the ligand of this receptor,prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.
Synonyms
PTGDR; prostaglandin D2 receptor (DP); prostaglandin D2 receptor; DP; DP1; PTGDR1; AS 1; AS1; ASRT 1; ASRT1; MGC49004; OTTHUMP00000178986; PD2R_HUMAN; PGD receptor; PGD2 receptor; Prostanoid DP receptor

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