PAK6

Official Full Name

p21 (RAC1) activated kinase 6

Organism

Homo sapiens

Gene ID

56924

Background

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Synonyms

PAK5

Cat.No.	Product Name	Price
CSC-DC011265	Panoply™ Human PAK6 Knockdown Stable Cell Line	Inquiry
CSC-SC011265	Panoply™ Human PAK6 Over-expressing Stable Cell Line	Inquiry
CSC-RT2656	Human PAK6 Knockout Cell Line-HEK293T	Inquiry

Cat.No.	Product Name	Price
AD11771Z	Human PAK6 adenoviral particles	Inquiry

Cat.No.	Product Name	Price
SHH370196	shRNA set against Human PAK6 (NM_020168.4)	Inquiry
SHH370200	shRNA set against Mouse PAK6 (NM_001033254.3)	Inquiry
SHH370204	shRNA set against Rat PAK6 (NM_001106498.1)	Inquiry
SHR064038	shRNA set against Rat Olr463_predicted(NM_001000934.1)	Inquiry
SHW013420	shRNA set against Danio rerio PAK6B (NM_001162487)	Inquiry

Cat.No.	Product Name	Price
CDCL145661	Mouse Pak6 ORF clone (NM_001033254.3)	Inquiry
CDFH013647	Human PAK6 cDNA Clone(NM_001128628.1)	Inquiry
CDFH013648	Human PAK6 cDNA Clone(NM_001128629.1)	Inquiry
CDFR006231	Rat Pak6 cDNA Clone(NM_001106498.1)	Inquiry
MiUTR3H-09743	PAK6 miRNA 3'UTR clone	Inquiry
MiUTR3H-09744	PAK6 miRNA 3'UTR clone	Inquiry
MiUTR3H-09745	PAK6 miRNA 3'UTR clone	Inquiry
CDCB174895	Danio rerio PAK6B ORF Clone (NM_001162487)	Inquiry
CDCB188493	Rabbit PAK6 ORF clone (XM_002717796.2)	Inquiry
CDCL185603	Human PAK6 ORF clone(NM_001128628.1)	Inquiry
CDCR238028	Mouse Pak6 ORF Clone(NM_001145854.1)	Inquiry
CDCR349104	Human PAK6 ORF Clone(NM_001128629.1)	Inquiry
CDCR373284	Rat Pak6 ORF Clone(NM_001106498.1)	Inquiry
CDCS407863	Human PAK6 ORF Clone (BC035596)	Inquiry

Detailed Information

PAK6 roles as a potential anti-cancer target

In subsequent to the first discovery of PAKs in designing novel antifungal agents by Manser and colleagues, its biology has attracted significant attention in the ensuing decades. In group II PAKs, PAK6 is less characterized than other members, and studies on its role as an interesting partner of AR in prostate cancer cells have been a focus since confirmed to be independent of Rho GTPases. As a 681 amino acid protein with a molecular mass of 75kDa, PAK6 is located on chromosome 15q15, its gene is at the length of 38kb and comprised of 17 transcripts. The existence of a conserved N-terminal CRIB and a C-terminal kinase catalytic domain is similar to other members of the PAK family. Be similar to the CRIB domains of the previously characterized PAKs, the N-terminus of PAK6 consisted by six of the eight common CRTB domain residues. And C-terminal of PAK6 share more than 50% similarity with PAK1-3 in sequence and 80% homology to PAK4, it may reflect the alternative mechanisms of kinase regulation.

PAK6 has been shown to be either deregulated or hyper-activated in a large number of human cancers in recent years, more than this, it has been shown with essential relatedness with many fundamental cellular processes typically deregulated in cancer, such as cell migration, differentiation, and survival. Aberrant expression of PAK6 in a large number of human diseases, including cancer, has been underpinned by accumulating data. For its function, even though there is a reasonable understanding of the signal-framework, some basic problems remain elusive. Different PAKs perform different or even opposite functions during cancer development while most are considered oncogenes. It may be the results of optimal phosphorylation sites, different effects of Cdc42 interactions, and alternative substrates, those factors fluctuated levels of regulation.

Cervical cancer progression promoted by PAK6 through Wnt/β-catenin signaling pathway activation

As a member of the serine/threonine kinase family, p21-activated kinase 6 (PAK6) has been reported to be involved in numerous cancers. Expression levels of Wnt/β-catenin signaling associate proteins can be modified by PAK6 knockdown, such as downregulation of GSK3β phosphorylation and Cyclin D1 protein, and upregulation of β-catenin phosphorylation and E-cadherin. And overexpression of PAK6 is accompanied by the activation of Wnt/β-catenin signaling pathway. Interaction between PAK6 with GSK3β was indicated by investigation in fluroscence microscopy and Co-IP assays. Those findings suggest that PAK6 may act as a promoter of cervical cancer by activation of the Wnt/β-catenin signaling pathway.

Figure 1. The epigenetic regulation of PAK6 in HCC. (Gong, et al. 2020)

References:

Gong C C, Li T T, Pei D S. PAK6: a potential anti-cancer target. Brazilian Journal of Pharmaceutical Sciences, 2020, 56.
Yang Q, Zhao Y, Chen Y, et al. PAK6 promotes cervical cancer progression through activation of the Wnt/βcatenin signaling pathway. Oncology Letters, 2020, 20(3): 2387-2395.

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PAK6

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Detailed Information

PAK6 roles as a potential anti-cancer target

Cervical cancer progression promoted by PAK6 through Wnt/β-catenin signaling pathway activation