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NEB


Official Full Name
nebulin
Organism
Homo sapiens
Gene ID
4703
Background
This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kD due to alternative splicing that is tissue-, species-,and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Of the several thousand transcript variants predicted for nebulin, the RefSeq Project has decided to create three representative RefSeq records. Mutations in this gene are associated with recessive nemaline myopathy. [provided by RefSeq, Sep 2009]
Synonyms
AMC6; NEM2; NEB177D

Cat.No. Product Name Price
SHH350968 shRNA set against Human NEB (NM_004543.4) Inquiry
SHH350972 shRNA set against Mouse NEB (NM_010889.1) Inquiry
Cat.No. Product Name Price
MiUTR3H-01515 NEB miRNA 3'UTR clone Inquiry
MiUTR3H-01516 NEB miRNA 3'UTR clone Inquiry
MiUTR3H-01517 NEB miRNA 3'UTR clone Inquiry
CDCB180365 Rabbit NEB ORF clone (XM_008258580.1) Inquiry
CDCH391601 Human NEB ORF clone(NM_004543.4) Inquiry
CDCH391602 Mouse NEB ORF clone(NM_010889.1) Inquiry
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