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KCNMA1


Official Full Name
potassium calcium-activated channel subfamily M alpha 1
Organism
Homo sapiens
Gene ID
3778
Background
This gene encodes the alpha subunit of calcium-activated BK channel. The encoded protein is involved in several physiological processes including smooth muscle contraction, neurotransmitter release and neuronal excitability. Mutations in this gene are associated with a spectrum of neurological disorders including Paroxysmal Nonkinesigenic Dyskinesia 3, Idiopathic Generalized Epilepsy 16 and Liang-Wang syndrome. [provided by RefSeq, Aug 2022]
Synonyms
SLO; BKTM; SLO1; hSlo; IEG16; LIWAS; MaxiK; PNKD3; SAKCA; mSLO1; CADEDS; KCa1.1; SLO-ALPHA; bA205K10.1

Cat.No. Product Name Price
SHH323531 shRNA set against Mouse KCNMA1 (NM_010610.3) Inquiry
SHL190524 shRNA set against Rat Kcnma1(NM_031828.1) Inquiry
SHW004740 shRNA set against Chicken KCNMA1 (NM_204224) Inquiry
Cat.No. Product Name Price
MiUTR1R-02836 KCNMA1 miRNA 3'UTR clone Inquiry
CDCG010876 Mouse KCNMA1 ORF clone(NM_001253367.1) Inquiry
CDFR012958 Rat Kcnma1 cDNA Clone(NM_031828.1) Inquiry
CDCG010853 Mouse KCNMA1 ORF clone(NM_001253372.1) Inquiry
CDFH009673 Human KCNMA1 cDNA Clone(NM_001161352.1) Inquiry
CDFH009674 Human KCNMA1 cDNA Clone(NM_001161353.1) Inquiry
CDCG013521 Mouse KCNMA1 ORF clone(NM_001253364.1) Inquiry
CDCR379972 Rat Kcnma1 ORF Clone(NM_031828.1) Inquiry
CDCR249313 Mouse Kcnma1 ORF Clone(NM_010610.3) Inquiry
CDCL123231 Human KCNMA1 ORF clone (NM_002247.3) Inquiry
CDCL123229 Mouse KCNMA1 ORF clone (NM_001161353.1) Inquiry
CDCL123227 Human KCNMA1 ORF clone (NM_001161352.1) Inquiry
CDCG013538 Mouse KCNMA1 ORF clone(NM_001253377.1) Inquiry
CDCG013536 Mouse KCNMA1 ORF clone(NM_001253371.1) Inquiry
CDCG013532 Mouse KCNMA1 ORF clone(NM_001253360.1) Inquiry
CDCG013529 Mouse KCNMA1 ORF clone(NM_001253376.1) Inquiry
CDCG013524 Mouse KCNMA1 ORF clone(NM_001253375.1) Inquiry
CDCS406558 Human KCNMA1 ORF Clone (BC062659) Inquiry
CDCG010882 Mouse KCNMA1 ORF clone(NM_001253358.1) Inquiry
CDCG010873 Mouse KCNMA1 ORF clone(NM_001253373.1) Inquiry
CDCG010867 Mouse KCNMA1 ORF clone(NM_001253362.1) Inquiry
CDCG010865 Mouse KCNMA1 ORF clone(NM_001253378.1) Inquiry
CDCG010861 Mouse KCNMA1 ORF clone(NM_001253366.1) Inquiry
CDCG010857 Mouse KCNMA1 ORF clone(NM_001253365.1) Inquiry
CDCG010849 Mouse KCNMA1 ORF clone(NM_001253370.1) Inquiry
CDCG010844 Mouse KCNMA1 ORF clone(NM_001253359.1) Inquiry
CDCG010843 Mouse KCNMA1 ORF clone(NM_001253374.1) Inquiry
CDCG010838 Mouse KCNMA1 ORF clone(NM_001253361.1) Inquiry
CDCG010836 Mouse KCNMA1 ORF clone(NM_001253369.1) Inquiry
CDCG010826 Mouse KCNMA1 ORF clone(NM_001253363.1) Inquiry
CDCB180282 Rabbit KCNMA1 ORF clone (NM_001082070.1) Inquiry
CDCG010880 Mouse KCNMA1 ORF clone(NM_001253368.1) Inquiry
CDCB166215 Chicken KCNMA1 ORF Clone (NM_204224) Inquiry

Detailed Information

Recent Research

The gene KCNMA1 (also named BK) encodes pore-forming potassium large-conductance calcium-activated channel proteins in the cell membrane.KCNMA1 is involved in the electrical activity of cells excitement,hormone secretion,neurotransmitter release, and contraction of blood vessels, the gastrointestinal tract,trachea, the uterus, the bladder and corpus cavernosum smooth muscle tissue, as well as in regulation of many other important physiological activities.

KCNMA1 was first reported as a disease gene in a large family with autosomal dominant generalized epilepsy and paroxysmal nonkine-sigenic dyskinesia, and in two unrelated children presenting with early-onset paroxysmal nonkine-sigenic dyskinesia and developmental delay carrying de novo mutations. Gain of function was proposed as the molecular mechanism that leads to increased excitability in such channel lesions. Neuroimaging findings were normal in all affected children. Its expression can cause functional ion channel-mediated intracellular K+ outflow, membrane hyperpolarization and a decrease in the excitability of cell.

The protein encoded by KCNMA1 represents the voltage and Ca2+-activated K+ channel, and is involved in the feedback inhibition of the action potential frequency and Ca2+ influx.New evidenceshave shown that Ca2+is closely related to cell apoptosis. Moreover, by bioinformatics analysis based on The Cancer Genome Atlas (TCGA), it has been found that KCNMA1 can regulate the expression of FAK (focal adhesion kinase), also known as PTK2, which is a non-receptor tyrosine kinase and moderate cancer proliferation, migration and survival. It may regulate cell apoptosis through the PI3K-AKT pathway. It is possible that the Ca2+ is involved in apoptosis by cooperating with PTK2.

In addition, BK channels can promote growth and spreading of breast, prostate and gliomas tumor. Some studies found that BK channels do not participate in glioma cell division and genetic knock-down of BKα assist osteosarcoma development. So the role of BK channel in human tumor may play a very complex one. It has been found that KCNMA1 was down-regulated in the tumor tissues due to the methylation of promoter and played a tumor suppressor role.

References:

  1. He Y, et al. Transplantation KCNMA1 modified bone marrow‐mesenchymal stem cell therapy fordiabetes mellitus‐induced erectile dysfunction. Andrologia, 2014, 46(5):479-486.
  2. Ma G, et al. KCNMA1 cooperating with PTK2 is a novel tumor suppressor in gastric cancer and is associated with disease outcome. Molecular Cancer, 2017, 16(1):46.
  3. Tabarki B, et al. HomozygousKCNMA1mutation as a cause of cerebellar atrophy, developmental delay and seizures. Human Genetics, 2016, 135(11):1295-1298.
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