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KIR2DL5A

Official Full Name
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and;subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome;19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among;haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The;KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have;a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals;upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short;cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to;transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR;proteins are thought to play an important role in regulation of the immune response.
Synonyms
KIR2DL5A; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A; CD158F; KIR2DL5; KIR2DL5.1

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