KCTD10

Official Full Name

potassium channel tetramerization domain containing 10

Organism

Homo sapiens

GeneID

83892

Background

The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

Synonyms

BTBD28; ULRO61; MSTP028; hBACURD3;

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Detailed Information

Recent Research

KCTD10 is a member of the polymerase delta-interacting protein 1 (PDIP1) gene family, which consists of 3 members, PDIP1, KCTD10 and TNFAIP1. All the three members contain a conserved BTB/POZ domain, a potassium channel tetramerisation (K-tetra) domain (a relative of BTB/POZ domain) at the N-terminus, and a proliferating cell nuclear antigen (PCNA)-binding motif at the C-terminus. KCTD10 is inducible by tumor necrosis factor-a (TNF-α), interacts with PCNA and the small subunit (p50) of DNA polymerase δ.

KCTD10 is composed of 313 amino acids, and its protein molecular size is about 35.4KD.The KCTD10 gene is highly conserved during revolution among human, mouse, ox, chicken and zebrafish. The expression of KCTD10 is tissue-specific. KCTD10 is highly expressed in the lung, heart and kidney of rats. In humans, KCTD10 is highly expressed in the heart, skeletal muscle and placenta. In addition, the expression level of KCTD10 in leukemia, lymphoma, cancer, colorectal gland, lung cancer, and melanoma cell lines is high.

It has been reported that KCTD10 plays an important role in cell development. One report has shown that KCTD10 interacts with proliferating cell nuclear antigens to increase DNA synthesis and cell proliferation in lung cancer cells. Moreover, studies showed that inhibition of KCTD10 expression increased invasion and metastasis of gastrointestinal stromal tumor cells, suggesting that KCTD10 may act as a tumor suppressor protein. Importantly, during the cardiac development, KCTD10 can directly bind to and inhibit the activity of the transcription factor TbxSa in cardiac heart formation, thereby affecting cardiac development and leading to congenital heart disease.

In human, KCTD10 down-regulation could inhibit cell proliferation. Transcription factors Sp1 and AP-2a could bind to proximal promoter region of human KCTD10, and regulate its expression. Reports showed that KCTD10 may regulate the neural tube, neuroepithelium and the dorsal root ganglion in mammals. Moreover, KCTD10 was reported to be regulated by a novel transcription factor ETV1 which is unique to gastrointestinal stromal tumors (GISTs), and RNAi-mediated silencing of KCTD10 increased cell invasion.

References:

Kaiqun R, et al. KCTD10 Is Involved in the Cardiovascular System and Notch Signaling during Early Embryonic Development. PLoS ONE, 2014, 9(11):e112275-.
Hu X, et al. KCTD10 is critical for heart and blood vessel development of zebrafish. Acta Biochimica et Biophysica Sinica, 2014, 46(5):377-386.

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