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Irgm2

Official Full Name
immunity-related GTPase family M member 2
Organism
Mus musculus
GeneID
54396
Background
Enables GTPase activity. Involved in several processes, including defense response to protozoan; negative regulation of non-canonical inflammasome complex assembly; and protein targeting to vacuolar membrane. Acts upstream of or within response to bacterium. Is active in Golgi membrane; cytosol; and vacuolar membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Irgm2; GTPI; Iigp2; Ifggd2;

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