FGF10

Official Full Name

fibroblast growth factor 10

Organism

Homo sapiens

GeneID

2255

Background

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

Synonyms

LADD3;

Cat.No.	Product Name	Price

Cat.No.	Product Name	Price

Cat.No.	Product Name	Price

Cat.No.	Product Name	Price

Detailed Information

In the view of the systematic evolution process, seven subfamilies can be subgrouped from the 22 Fgf genes, including Fgf-1, Fgf-4, Fgf-7, Fgf-8, Fgf-9, Fgf-11 and Fgf-15/19. And those subfamilies can be further divided into the following categories by their biological functions: canonical Fgf (Fgf-1, Fgf-4, Fgf-7, Fgf-8, Fgf-9), endocrine Fgf (Fgf-15/19) and intracellular Fgf (Fgf-11). As a member of the subfamily of Fgf-7, Fgf-10 is a 208 amino acid composited peptide with the heparin-binding affinity and similarity in function and structure of the keratinocyte growth factor-2. The 3D organ modeling research manifested the synergistic effect of Fgf-10 and Wnt signaling pathway plays a pivotal role in the repair after the lung epithelial cell's injury. And Fgf-10 is secreted from mesenchymal-derived cells in the lung, whose closely binding with the heparin sulfate proteoglycans would influence its stability, dispersion, and affinity with the Fgf receptor. The formation of Fgf-10-HSPG(heparin sulfate proteoglycans)-FGFR2 polymer complex can active the tyrosine kinase of the downstream receptor and the activation of the AMPK-AKT signaling pathway can be induced by the binding of Fgf-10 and Fgfr2Ⅲb receptor. Immediately phosphorylation of 734 tyrosine on the Fgfr2Ⅲb receptor upon its binding with Fgf-10 would further convene the PI3K and SH3BP4(SH3-domain-binding protein 4) complex for the recycling of the receptor.

Fgf-10 on The Regulation of Lung Development and Repair After Injury

Even though the mechanism about protection effect of Fgf-10 on acute lung injury is still under exploration, it is clear how it acts on the endothelial, epithelial and mesenchymal stem cells that emphasized cell-lineage in the lung disease progression. The proliferation of airway and alveolar epithelial cells stimulated by the Fgf-10 would restore and heal the compactness of the blood-air barrier after its coverage and immigration onto the injured area. Significantly lower expression of pulmonary surfactant protein can be reversed by Fgf-10, thus maintained the blood-air barrier’s homeostasis. Inhibition of hypoxia-induced pulmonary microvascular endothelial cells apoptosis due to the upregulation of AKT by Fgf-10 is partially blocked by the PI3K or EGFR suppression. Extraction of mesenchymal stem cells from alveolar lavaging can be completed by dripping Fgf-10 onto the airway because of the highly expressed Fgf-10 receptor on the mesenchymal stem cells and congregation effect. Then with expanded culturing in vitro of those extracted cells infused into the acutely injured lung of the rat model, the symptom of which can be significantly relieved. And stem cells of mesenchymal shows superiority in the protective effect on lung injury than bone marrow one's due to its unique functionality and intracellular signaling activation characteristics.

Clinic Use of Fgf-10 in Human Disease

Some clinical trials about the efficacy of Fgf-10 for refractory ulcerative colitis, diabetic venous ulcers, chemotherapy-induced oral mucositis, and refractory epithelial injuries have confirmed the safety of Fgf-10 in the human body. Even though it is clear that Fgf-10 is involved in the regulation of cell proliferation, migration, differentiation, apoptosis and embryonic development, the biological features and how it works on the embryo and individuals after birth has not been fully understood yet, especially in the mechanism of its mesenchymal stem cell-convening effect. Beyond the protective effect on the stimulation exposure induced acute lung injury and airway damage, Fgf-10, as paracrine protein suitable for local administration, recombinant protein use of which is expected to be a new strategy and breakthrough in the treatment of human disease.

Fig 1. Wnt7b-Fgf10 epithelial-mesenchymal crosstalk (Yuan et al. 2018)

References:

Agha, E. and Bellusci, S. (2014) 'Walking along the Fibroblast Growth Factor 10 Route: A Key Pathway to Understand the Control and Regulation of Epithelial and Mesenchymal Cell-Lineage Formation during Lung Development and Repair after Injury', Scientifica, 538379.
Ornitz, D. and Itoh, N. (2015) 'The Fibroblast Growth Factor signaling pathway', Advanced Review, 4, 215–266.
Yuan T., Volckaert T., Chanda D., Thannickal V. and De Langhe SP., (2018) 'Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury'. Front. Genet. 9, 418. doi: 10.3389/fgene.2018.00418.

Quick Inquiry

Interested in learning more?

Contact us today for a free consultation with the scientific team and discover how Creative Biogene can be a valuable resource and partner for your organization.

Request a quote today!

Inquiry