ELF1

Official Full Name

E74 like ETS transcription factor 1

Organism

Homo sapiens

Gene ID

1997

Background

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Synonyms

RIA1; EFTUD1

Cat.No.	Product Name	Price
CSC-DC004755	Panoply™ Human EFNA2 Knockdown Stable Cell Line	Inquiry
CSC-DC004853	Panoply™ Human ELF1 Knockdown Stable Cell Line	Inquiry
CSC-DC004874	Panoply™ Human ELOF1 Knockdown Stable Cell Line	Inquiry
CSC-DC013950	Panoply™ Human SEC24C Knockdown Stable Cell Line	Inquiry
CSC-SC004755	Panoply™ Human EFNA2 Over-expressing Stable Cell Line	Inquiry
CSC-SC004853	Panoply™ Human ELF1 Over-expressing Stable Cell Line	Inquiry
CSC-SC004874	Panoply™ Human ELOF1 Over-expressing Stable Cell Line	Inquiry
CSC-SC013950	Panoply™ Human SEC24C Over-expressing Stable Cell Line	Inquiry
CSC-RT1101	Human ELOF1 Knockout Cell Line-HEK293T	Inquiry
CLKO-0591	ELOF1 KO Cell Lysate-HEK293T	Inquiry
CSC-RT2671	Human SEC24C Knockout Cell Line-Hela	Inquiry

Cat.No.	Product Name	Price
AD05301Z	Human EFNA2 adenoviral particles	Inquiry
AD05406Z	Human Elf1 adenoviral particles	Inquiry
AD05426Z	Human ELOF1 adenoviral particles	Inquiry
AD14387Z	Human SEC24C adenoviral particles	Inquiry
LV11482L	human EFNA2 (NM_001405) lentivirus particles	Inquiry
LV11640L	human ELF1 (NM_172373) lentivirus particles	Inquiry
LV11641L	human ELF1 (NM_001145353) lentivirus particles	Inquiry
LV11668L	human ELOF1 (NM_032377) lentivirus particles	Inquiry
LV24917L	human SEC24C (NM_198597) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHH031049	shRNA set against Rat Elf1(NM_053520.2)	Inquiry
SHH031583	shRNA set against Human ELOF1(NM_032377.3)	Inquiry
SHH031043	shRNA set against Mouse Elf1(NM_007920.3)	Inquiry
SHW013967	shRNA set against Danio rerio SEC24C (NM_001245968)	Inquiry
SHW005484	shRNA set against Chicken EFNA2 (NM_204983)	Inquiry
SHW000358	shRNA set against Chicken ELF1 (NM_001006269)	Inquiry
SHL029676	shRNA set against Rat Spnb2(NM_001013130.1)	Inquiry
SHH416956	shRNA set against Mouse Spnb2 (NM_009260.2)	Inquiry
SHH403836	shRNA set against Rat SEC24C (NM_001109456.1)	Inquiry
SHH403832	shRNA set against Mouse SEC24C (NM_172596.2)	Inquiry
SHH403828	shRNA set against Human SEC24C (NM_004922.3)	Inquiry
SHH285237	shRNA set against Mouse ELOF1 (NM_170777.3)	Inquiry
SHH285233	shRNA set against Human ELOF1 (NM_032377.3)	Inquiry
SHH285001	shRNA set against Rat Elf1 (NM_053520.2)	Inquiry
SHH284997	shRNA set against Mouse Elf1 (NM_007920.3)	Inquiry
SHH283641	shRNA set against Rat EFNA2 (NM_001168670.1)	Inquiry
SHH283637	shRNA set against Mouse EFNA2 (NM_007909.3)	Inquiry
SHH283633	shRNA set against Human EFNA2 (NM_001405.3)	Inquiry
SHH222252	shRNA set against Mouse Spnb2(NM_009260.2)	Inquiry
SHH222234	shRNA set against Mouse Spnb2(NM_175836.2)	Inquiry
SHH031565	shRNA set against Mouse Elof1(NM_170777.3)	Inquiry
SHW014537	shRNA set against Danio rerio EFNA2A (NM_131022)	Inquiry
SHW016587	shRNA set against Danio rerio ELOF1 (NM_200386)	Inquiry

Cat.No.	Product Name	Price
SKO0456	ELOF1 Validated sgRNA vector	Inquiry
CDFH005843	Human ELF1 cDNA Clone(NM_001145353.1)	Inquiry
CDFL012984	Mouse Spnb2 cDNA Clone(NM_009260.2)	Inquiry
CDFL012985	Mouse Spnb2 cDNA Clone(NM_175836.2)	Inquiry
CDFR008992	Rat Sec24c cDNA Clone(NM_001109456.1)	Inquiry
CDFR009464	Rat Elof1 cDNA Clone(NM_001126098.1)	Inquiry
CDFR013245	Rat Elf1 cDNA Clone(NM_053520.2)	Inquiry
CDCR059812	Mouse Elf1 ORF clone (NM_007920.3)	Inquiry
MiUTR1H-03189	ELF1 miRNA 3'UTR clone	Inquiry
MiUTR1H-03205	ELOF1 miRNA 3'UTR clone	Inquiry
MiUTR1M-04355	ELF1 miRNA 3'UTR clone	Inquiry
MiUTR1M-04366	ELOF1 miRNA 3'UTR clone	Inquiry
MiUTR1M-11181	SPNB2 miRNA 3'UTR clone	Inquiry
CDCB192073	Rabbit ELF1 ORF clone (XM_008260024.1)	Inquiry
MiUTR1M-11182	SPNB2 miRNA 3'UTR clone	Inquiry
MiUTR1R-01708	ELF1 miRNA 3'UTR clone	Inquiry
MiUTR3H-02255	ELF1 miRNA 3'UTR clone	Inquiry
MiUTR3H-09030	SEC24C miRNA 3'UTR clone	Inquiry
CDCB166959	Chicken EFNA2 ORF Clone (NM_204983)	Inquiry
MiUTR3H-09031	SEC24C miRNA 3'UTR clone	Inquiry
MiUTR4H-TG02985	EFNA2 miRNA 3'UTR clone	Inquiry
CDCS418496	Human ELOF1 ORF Clone (BC007516)	Inquiry
CDCS408494	Human ELF1 ORF Clone (BC030507)	Inquiry
CDCR380162	Rat Elf1 ORF Clone(NM_053520.2)	Inquiry
CDCB161833	Chicken ELF1 ORF Clone (NM_001006269)	Inquiry
CDCB175442	Danio rerio SEC24C ORF Clone (NM_001245968)	Inquiry
CDCB176012	Danio rerio EFNA2A ORF Clone (NM_131022)	Inquiry
CDCB178062	Danio rerio ELOF1 ORF Clone (NM_200386)	Inquiry
CDCB183401	Rabbit SEC24C ORF clone (XM_008269947.1)	Inquiry
CDCH017071	Human EFNA2 ORF clone(NM_001405.3)	Inquiry
CDCH078002	Mouse Sec24c ORF clone (NM_001168273.1)	Inquiry
CDCL183998	Mouse EFNA2 ORF clone(NM_007909.3)	Inquiry
CDCL183999	Rat EFNA2 ORF clone(NM_001168670.1)	Inquiry
CDCR059808	Human ELF1 ORF clone (NM_001145353.1)	Inquiry
CDCR059816	Mouse Elof1 ORF clone (NM_170777.3)	Inquiry
CDCR059818	Mouse Spnb2 ORF clone (NM_175836.2)	Inquiry
CDCR246861	Mouse Spnb2 ORF Clone(NM_009260.2)	Inquiry
CDCR376039	Rat Sec24c ORF Clone(NM_001109456.1)	Inquiry
CDCR376525	Rat Elof1 ORF Clone(NM_001126098.1)	Inquiry
CDCS417825	Human SEC24C ORF Clone (BC018928)	Inquiry
CDCB156287	Cynomolgus ELOF1 ORF clone (NM_001190902.1)	Inquiry

Detailed Information

The ELF1 (E74-like factor 1) gene is a T cell-specific transcription factor in the Ets family, most representative of which has been found to be highly active in many human tumors. Ets (erythroblast transformation specific) gene is a type of oncogene composed of a series of highly conserved homologous sequences involved in the regulation of tumor invasion and metastasis. More than 20 members have been found.

ELF1 Figure 1. The role of ELF1 in the development of lupus T cells. (Mak, et al. 2016)

Expression of ELF1 in Tumors

Breast cancer is the most common malignant tumor in women's life in developed countries. Kalet et al. found that ELF1 promotes breast cancer progression in four ERA (estrogen receptor A)-positive breast cancer cell lines. The proliferation, migration and invasion characteristics of ELF1 transcription factors were verified in MCF7 clonal cells. The growth rate of MCF7 tumor cells with high expression of ELF1 was significantly increased, while the control group was lower. Tumors with high expression of ELF1 showed a large central necrosis and increased apoptosis of apoptosis.

Pancreatic cancer is one of the ten common malignant tumors. It is difficult to find in the early stage. After the diagnosis is clear, it is most advanced and the prognosis is poor. Li et al. studied the role of ELF1 in epithelial-mesenchymal transition (EMT) and found that ELF1 gene expression was positively correlated with N-cadherin and negatively correlated with E-cadherin mRNA. To further study the role of ELF1, short hairpin constructs carrying ELF1 ribose acid (shRNA) expression of the green fluorescent protein, and the plasmid was transfected into pancreatic cancer cells. Studies have found that knocking out ELF1 in this pancreatic cancer cell line attenuates the effects of EMT. A decrease in cell migration and adhesion and a decrease in metastasis rate were observed in these cells, further indicating that the gene is involved in the development of pancreatic cancer.

RhoC is a member of the Rho family of Ras superfamily homologous gene families and has been shown to be involved in tumorigenesis and tumor progression. Hepatitis B virus proteins play an important role in the development and progression of hepatocellular carcinoma (HCC). Qin et al. have shown that high expression of ELF1 up-regulates RhoC promoter activity and mRNA and protein levels. Hepatitis B virus-adenovirus recombinant virus infection can lead to up-regulation of ELF1, which in turn leads to tumorigenesis.

ELF1 Promotes Tumorigenesis and Development

Survivin is the strongest inhibitor of apoptosis in the current inhibitor of apoptosis protein (IAP). It has been reported that the expression of ELF1 in non-small cell lung cancer is positively correlated with survivin. The researchers used immunohistochemistry and in situ end labeling (TUNEL) to demonstrate that ELF1 expression was negatively correlated with tumor cell apoptosis in non-small cell lung cancer tissues. The degradation of most regulatory proteins in eukaryotic cells is through the ubiquitin-proteasome pathway, which regulates the ubiquitin-proteasome pathway and regulates cell apoptosis and growth.

Ki-67 antigen is involved in cell division and proliferation. The marker index of Ki-67 can reliably and rapidly reflect the proliferation rate of malignant tumors, which is related to the development, metastasis, and prognosis of various malignant tumors. Kong et al. used tissue microarray and immunohistochemistry to find that the expression of ELF1 and Ki-67 protein in 64 lung cancer tissues was significantly higher than that in 10 normal lung tissues, and the expression level was related to tumor differentiation, clinical stage, and lymph node metastasis. At the same time, it was found that ELF1 was positively correlated with Ki-67 expression. Subsequently, Furlan et al also found a positive correlation between the ratio of Etf-1 and Ki67-positive cells in breast cancer tumorigenic models, which promoted tumor growth and inhibited tumor growth and metastasis after knocking out the gene. Studies have shown that Etf-1 expression is associated with cancer invasion and prognosis.

References:

Pali-Schöll, I., & Jensen-Jarolim, E. (2016). The concept of allergen-associated molecular patterns (aamp). Current Opinion in Immunology, 42, 113-118.
Yin, Y., Sanders, A. J., Feng, L., & Jiang, W. G. (2014). Knockdown of aamp impacts on hecv cell functions in vitro and affects the expression of ve-cadherin. Angiology, 2(2), 1000125.
Kalet, B. T., Anglin, S. R., Handschy, A., O’Donoghue, L. E., Halsey, C., & Chubb, L., et al. (2013). Transcription factor ets1 cooperates with estrogen receptor α to stimulate estradiol-dependent growth in breast cancer cells and tumors. Plos One, 8(7), e68815.
Chunyan, L. I., Wang, Z., Chen, Y., Zhou, M., Zhang, H., & Chen, R., et al. (2015). Transcriptional silencing of ets-1 abrogates epithelial-mesenchymal transition resulting in reduced motility of pancreatic cancer cells. Oncology Reports, 33(2), 559-565.
Qin, D., Li, K., Qu, J., Wang, S., Zou, C., & Sheng, Y., et al. (2013). Hbx and hbs regulate rhoc expression by upregulating transcription factor ets-1. Archives of Virology, 158(8), 1773-1781.
Kong, L., Zhang, H., Ma, Y., Hu, J., & Yang, D. (2009). Expression of elf-1 and its relationship with survivin and ki-67 in non-small-cell lung cancer. Modern Journal of Integrated Traditional Chinese & Western Medicine.
Furlan, A., Vercamer, C., Bouali, F., Damour, I., Chotteau-Lelievre, A., & Wernert, N., et al. (2015). Ets-1 controls breast cancer cell balance between invasion and growth. International Journal of Cancer, 135(10), 2317-2328.
Mak, A., & Kow, N. Y. (2014). The pathology of t cells in systemic lupus erythematosus. Journal of Immunology Research,2014,(2014-4-23), 2014(22), 419029.

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