DCBLD2

Official Full Name

discoidin, CUB and LCCL domain containing 2

Organism

Homo sapiens

GeneID

131566

Background

Predicted to enable signaling receptor activity. Involved in negative regulation of cell growth and wound healing. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Feb 2025]

Synonyms

ESDN; CLCP1;

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Detailed Information

The DCBLD2 gene, also known as Dedicator of cytokinesis 2, is a cytoplasmic protein that is highly expressed in various tissues and cells, including fibroblasts, epithelial cells, and endothelial cells. The protein is encoded by the DCBLD2 gene, which is located on human chromosome 10q23.1. The gene consists of 10 exons and encodes a protein of 461 amino acids. DCBLD2 is a relatively newly discovered gene that has piqued the interest of researchers due to its potential role in various cellular processes and its implications in human health and disease.

Structure And Expression of DCBLD2

DCBLD2 (Discoidin, CUB and LCCL domain-containing 2) is a gene that encodes a protein possessing Discoidin, CUB, and LCCL domains. These domains are characterized by their distinct structural features and functional roles in various cellular processes. The Discoidin domain, present in the N-terminal region of DCBLD2, is responsible for the protein's interaction with extracellular matrices and cell surfaces. This domain is evolutionarily conserved and is found in many proteins involved in cell adhesion, migration, and signaling. The CUB (CUB-like) domain, located in the central region of DCBLD2, is an immunoglobulin-like domain that mediates protein-protein interactions. This domain is involved in cell signaling, protein trafficking, and cell attachment. In DCBLD2, the CUB domain interacts with other cellular components, contributing to the overall function of the protein.The LCCL (Laminin, Collagen, and Fibronectin-like) domain, located in the C-terminal region of DCBLD2, shares similarity with laminin, collagen, and fibronectin. This domain is involved in cell signaling, cell adhesion, and extracellular matrix organization. It interacts with various cellular components and plays a crucial role in regulating cell behavior and tissue structure. Together, the Discoidin, CUB, and LCCL domains of DCBLD2 contribute to the overall structural and functional complexity of the protein.

DCBLD2 Affects Cardiovascular Disease

DCBLD2 gene has been implicated in cardiovascular disease pathogenesis, playing a pivotal role in several cellular processes that contribute to the development and progression of cardiovascular conditions. DCBLD2 interacts with components of the extracellular matrix (ECM), influencing cell signaling, adhesion, and migration. Abnormalities in these processes can lead to inappropriate cell proliferation, inflammation, and fibrosis - key factors associated with cardiovascular disease.

In the context of atherosclerosis, DCBLD2 has been found to regulate the expression of genes involved in macrophage recruitment, lipid metabolism, and plaque stability. Increased expression of DCBLD2 has been linked to enhanced macrophage migration and foam cell formation, promoting atherosclerotic plaque development. Moreover, studies have demonstrated that DCBLD2 is involved in the pathogenesis of hypertensive heart disease. Inhibition of DCBLD2 expression attenuates cardiomyocyte hypertrophy and fibrosis, suggesting that DCBLD2 may represent a potential therapeutic target for hypertensive heart disease.In addition, DCBLD2 has been implicated in remodeling and fibrosis processes following myocardial infarction. The Discoidin and LCCL domains of DCBLD2 interact with ECM components, influencing fibroblast activation and collagen deposition. This contributes to the formation of fibrotic scar tissue, which can lead to diastolic dysfunction and limit heart failure progression.

Overall, the role of DCBLD2 in cardiovascular disease pathogenesis highlights the importance of understanding the complex interactions between genetic factors, cell signaling, and ECM regulation in the development and progression of cardiovascular conditions.

References:

Chen, Xiaosu et al. "DCBLD2 Mediates Epithelial-Mesenchymal Transition-Induced Metastasis by Cisplatin in Lung Adenocarcinoma." Cancers vol. 13,6 1403. 19 Mar. 2021, doi:10.3390/cancers13061403
Li, Xiaomin et al. "Systematic analysis of the long noncoding RNA (lncRNA)-miRNA-mRNA competing endogenous RNA network to identify prognostic biomarkers and the potential regulatory axis in glioblastoma multiforme." Translational cancer research vol. 10,11 (2021): 4739-4755. doi:10.21037/tcr-21-1162

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