DEPDC1

Official Full Name

DEP domain containing 1

Organism

Homo sapiens

Gene ID

55635

Background

Predicted to enable GTPase activator activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Feb 2025]

Synonyms

DEP.8; SDP35; DEPDC1A; DEPDC1-V2

Cat.No.	Product Name	Price
CSC-DC004223	Panoply™ Human DEPDC1 Knockdown Stable Cell Line	Inquiry
CSC-SC004223	Panoply™ Human DEPDC1 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
AD04786Z	Human DEPDC1 adenoviral particles	Inquiry
LV10604L	human DEPDC1 (NM_017779) lentivirus particles	Inquiry
LV10605L	human DEPDC1 (NM_001114120) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHH001559	shRNA set against Human DEPDC1(NM_017779.4)	Inquiry
SHH277138	shRNA set against Mouse DEPDC1 (NM_178683.4)	Inquiry
SHW001083	shRNA set against Chicken DEPDC1 (NM_001012928)	Inquiry

Cat.No.	Product Name	Price
CDCS407663	Human DEPDC1 ORF Clone (BC065304)	Inquiry
CDFH004988	Human DEPDC1 cDNA Clone(NM_001114120.1)	Inquiry
MiUTR1H-02777	DEPDC1 miRNA 3'UTR clone	Inquiry
CDCB162558	Chicken DEPDC1 ORF Clone (NM_001012928)	Inquiry
CDCB186663	Rabbit DEPDC1 ORF clone (XM_008265076.1)	Inquiry
CDCR054974	Human DEPDC1 ORF clone (NM_001114120.1)	Inquiry

Detailed Information

The DEP structural domain is a globular domain consisting of approximately 90 amino acids that was first identified in three proteins: D. melanogaster Dishevelled, C. elegans EGL-10, and mammalian Pleckstrin, which are involved in Wnt signaling, G protein-coupled receptor signaling, and platelet and neutrophil signaling, respectively. These proteins are involved in Wnt signaling, G protein-coupled receptor signaling and platelet and neutrophil signaling, respectively.

Role of DEPDC1 in Tumor Development and Progression

DEPDC1 (DEP domain containing 1), Several studies have shown that DEPDC1 is aberrantly overexpressed in a wide range of human cancers and acts as an oncogene during tumorigenesis and progression. In a former study, the essential requirement of DEPDC1 to accelerate cell cycle progression and movement through the NF-κB signaling pathway in nasopharyngeal carcinoma has been reported. In other study, researchers found that DEPDC1 plays an oncogenic role in prostate cancer through activation of E2F signaling, which has a broad impact on the progression of HCC.

DEP domain containing 1 (DEPDC1) is a highly conserved protein that has been reported to act as a transcriptional repressor in bladder cancer cells. It represses A20 transcription by forming a complex with ZNF224, which activates the anti-apoptotic pathway through NF-κB via activation of NF-κB. A recent report showed that DEPDC1 promotes JNK-dependent degradation of MCL1 (an anti-apoptotic cell) in HeLa and MCF-7 cells, thereby inhibiting apoptosis. Thus, apoptosis was inhibited. Several reports in bladder, breast and lung cancers suggest that upregulation of DEPDC1 may play an important role in tumor-igenesis.

Molecular Targeted Therapy Strategies against DEPDC1

Given the critical role of DEPDC1 in tumor development and progression, molecular targeted therapy strategies against this gene have gained significant attention. Strategies include gene amplification, gene transfer, and small molecule inhibitors. Preclinical studies have shown that restoring DEPDC1 expression in tumor cells can inhibit tumor growth and metastasis. Moreover, targeting DEPDC1 has the potential to enhance the efficacy of existing cancer therapies and reduce drug resistance.

References:

Wang Q, Li A, Jin J, Huang G. Targeted interfering DEP domain containing 1 protein induces apoptosis in A549 lung adenocarcinoma cells through the NF-κB signaling pathway. Onco Targets Ther. 2017;10:4443-4454. Published 2017 Sep 11. doi:10.2147/OTT.S142244
Shen X, Han J. Overexpression of gene DEP domain containing 1 and its clinical prognostic significance in colorectal cancer. J Clin Lab Anal. 2020;34(12):e23634. doi:10.1002/jcla.23634

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