DDA1

Official Full Name

DET1 and DDB1 associated 1

Organism

Homo sapiens

GeneID

79016

Background

Involved in protein polyubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Feb 2025]

Synonyms

PCIA1; C19orf58;

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Detailed Information

The DET1 and DDB1 associated 1 (DDA1) gene is an essential regulator of various cellular processes, including cell cycle progression, DNA repair, and genome stability. mutations in the DDA1 gene have been linked to various human diseases, including cancer and neurodegenerative disorders.

Function And Structure of DDA1

The DDA1 gene encodes a protein of the same name, which is a member of the BTB (Broad Complex, Tramtrack, and Bric-a-brac) protein family. The DDA1 protein is a nuclear protein that contains a BTB domain, a C-terminal region, and a variable N-terminal region. The BTB domain is responsible for the protein's DNA binding activity, while the C-terminal region is involved in protein-protein interactions. The N-terminal region contains several conserved domains, including the WD-repeat domain, which is responsible for the protein's role in cell cycle regulation. DET1 and DDB1 Associated 1 (DDA1) is a gene associated with melanoma, a malignant skin cancer. It is located on chromosome 9 and is involved in the regulation of cell growth and differentiation. The structure of the DDA1 gene consists of 11 exons and 10 introns, encoding a protein of 351 amino acids. The gene is expressed in various tissues, including the skin, and its expression is often decreased in melanoma tumors. Understanding the structure and function of the DDA1 gene is important for developing targeted therapeutics against melanoma.

DDA1 in Cell Cycle Regulation

DDA1 plays a crucial role in cell cycle regulation, particularly in the G1/S transition. The protein interacts with androgen receptor (AR), retinoblastoma protein (Rb), and CDK4/6, which are key players in the cell cycle regulatory machinery. DDA1 binds to the AR and Rb, and inhibits their transcriptional activity, thereby promoting cell cycle progression. In addition, DDA1 interacts with CDK4/6 and promotes their kinase activity, which is essential for the G1/S transition.

DDA1 in DNA Repair and Genome Stability

DDA1 has also been implicated in DNA repair and genome stability. The protein interacts with various DNA repair enzymes, including DNA polymerase delta (polδ) and DNA ligase IV (LIG4), and promotes their activity. This interaction is crucial for the repair of DNA double-strand breaks (DSBs), which are common sources of genome instability. DDA1 also interacts with the checkpoint kinase CHK1, which is involved in the cellular response to DNA damage. Thus, DDA1 plays a crucial role in maintaining genome stability by regulating DNA repair pathways.

DDA1 in Human Diseases

mutations in the DDA1 gene have been identified as a cause of various human diseases. For example, mutations in the DDA1 gene have been linked to cancer, particularly breast cancer. In addition, DDA1 has been implicated in neurodegenerative disorders such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). DDA1 has also been identified as a potential therapeutic target for various diseases, including cancer and neurodegenerative disorders.

References:

Cheng, Lin et al. "DDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle." Journal of cellular and molecular medicine vol. 21,8 (2017): 1532-1544. doi:10.1111/jcmm.13084
Tang, Xiaofeng et al. "Ubiquitin-conjugated degradation of golden 2-like transcription factor is mediated by CUL4-DDB1-based E3 ligase complex in tomato." The New phytologist vol. 209,3 (2016): 1028-39. doi:10.1111/nph.13635

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