DCDC5

Official Full Name

doublecortin domain containing 5

Synonyms

RGD1562221;

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Detailed Information

The Doublecortin (DCX) family of proteins is a group of highly conserved proteins that share a common domain, the doublecortin domain (DCX domain). The DCX domain is characterized by a cysteine-rich region and is found in proteins that play crucial roles in various cellular processes, including neuronal development, migration, and synaptic plasticity. One member of this family, Doublecortin domain containing 5 (DCDC5), has gained significant attention due to its diverse functional properties and its involvement in several cellular processes.

Structure And Domain Organization of DCDC5

DCDC5 is a protein of approximately 143 kDa that belongs to the DCX family of proteins. The protein shares high similarity with other family members, such as DCX and DCDC2, in terms of sequence and domain organization. The DCDC5 protein consists of a signal peptide, a DCX domain, a coiled-coil domain, a leucine-rich repeat (LRR) domain, and a proline-rich region. The DCX domain is the most conserved region among DCDC5 and other DCX family members, and it is responsible for the homophilic binding of these proteins.

Function And Cellular Localization of DCDC5

The function of DCDC5 is still under investigation, but it is known to be involved in various cellular processes, including cell migration, axon guidance, and synaptic plasticity. studies have shown that DCDC5 interacts with other cellular proteins, such as the actin cytoskeletal protein, microtubules, and other DCX family members, to regulate cell migration and axon guidance. In addition, DCDC5 has been shown to be localized in the cytoplasm, neuronal processes, and synapses, suggesting its role in the regulation of synaptic plasticity.

DCDC5 Interacts with The Actin Cytoskeleton and Microtubules

The gene DCDC5 is a crucial player in the regulation of actin cytoskeleton and microtubule dynamics, which are essential for maintaining cell structure and function. Actin cytoskeleton and microtubules are responsible for cell motility, division, and differentiation.

DCDC5 encodes a protein that interacts with the actin cytoskeleton and microtubules. This protein is involved in the regulation of cytoskeletal proteins, such as actin and tubulin, which form the basis of actin filaments and microtubules, respectively. The interaction of DCDC5 with these proteins plays a significant role in modulating their assembly and disassembly, leading to appropriate cell behavior.

Actin cytoskeleton and microtubules are dynamic structures, constantly undergoing remodeling and regulation. The gene DCDC5 contributes to this process by regulating the interaction between actin and microtubules, ensuring proper cell morphology and function. Impairment in the expression or function of DCDC5 can lead to defects in cell mobility, division, and ultimately, compromised physiological processes.

Reference:

Kaplan, Anna, and Orly Reiner. "Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein." Journal of cell science vol. 124,Pt 23 (2011): 3989-4000. doi:10.1242/jcs.085407

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