DCDC1

Official Full Name

doublecortin domain containing 1

Organism

Homo sapiens

GeneID

341019

Background

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010]

Synonyms

DCDC5;

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Detailed Information

The Doublecortin (DCX) domain is a conserved domain found in several proteins that share similarities in structure and function. The Doublecortin domain-containing 1 (DCDC1) gene is one such protein that belongs to this family. The DCDC1 protein shares a common DCX domain with other proteins, which suggests that it might have similar functions and structural characteristics. Over the years, studies have shown that DCDC1 is involved in various cellular processes, including cell migration, axon guidance, and neurogenesis.

Function And Structure of DCDC1

The DCDC1 protein is a cytoplasmic protein that is highly conserved across various species. The primary function of DCDC1 is to regulate the activity of proteins involved in intracellular signaling pathways.

The structure of DCDC1 is also similar to that of other DCX domain-containing proteins. It has been reported that the DCX domain of DCDC1 forms a beta-β-β sandwich structure, which is a common structural feature of many proteins involved in signaling pathways. This structural similarity suggests that DCDC1 might play a crucial role in regulating signaling cascades, similar to other DCX domain-containing proteins. The DCX domain found in DCDC1 is responsible for its interaction with other cellular proteins, which helps to modulate signaling cascades. This domain is also found in other proteins like Dishevelled (DSH), which is a key regulator in the Wnt signaling pathway.

Expression of DCDC1

The expression of DCDC1 is highly regulated, and its expression levels can vary depending on the cell type and developmental stage. In general, DCDC1 is expressed in cells that are capable of migrating or undergoing differentiation, such as neurons and epithelial cells. DCDC1 is expressed during early stages of embryonic development, and its expression is closely associated with the development of the nervous system.

DCDC1 has also been found to be expressed in various human cancers, including colorectal cancer, breast cancer, and gastric cancer. The expression of DCDC1 in these cancers suggests that it might play a role in tumorigenesis and progression. Furthermore, the mutation or deletion of the DCDC1 gene has been reported in various cancers, which further emphasizes its potential role in human diseases.

Role of DCDC1 in Cancer

DCDC1 gene has recently emerged as a potential player in the development of cancer. This gene is involved in the regulation of cell migration, differentiation, and proliferation, processes that are critically altered in cancer cells. DCdc1 is expressed in various tissues, including the colon, breast, and lung, where it plays a role in maintaining the integrity of the epithelial barrier. Mutations and alterations in the DCDC1 gene are commonly observed in cancer cells. These mutations lead to the impairment of normal cell functions, resulting in uncontrolled cell growth and tumorigenesis. Moreover, Decreased expression of DCDC1 is associated with more aggressive tumor behavior and poorer prognosis in patients with cancer. DCDC1 interacts with other key molecules in the cell, such as the Hippo signaling pathway and the NOTCH signaling pathway, which are known to regulate cell fate and survival. These interactions suggest that DCDC1 may act as a tumor suppressor gene, preventing the onset of cancer by maintaining cellular homeostasis.

References:

Bechstedt, S et al. "A doublecortin containing microtubule-associated protein is implicated in mechanotransduction in Drosophila sensory cilia." Nature communications vol. 1,1 11. 12 Apr. 2010, doi:10.1038/ncomms1007
Horesh, D et al. "Doublecortin, a stabilizer of microtubules." Human molecular genetics vol. 8,9 (1999): 1599-610. doi:10.1093/hmg/8.9.1599

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