DBX2

Official Full Name

developing brain homeobox 2

Organism

Homo sapiens

GeneID

440097

Background

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including G2/M transition of mitotic cell cycle; epidermal growth factor receptor signaling pathway; and neural precursor cell proliferation. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Feb 2025]

Cat.No.	Product Name	Price

Cat.No.	Product Name	Price

Cat.No.	Product Name	Price

Cat.No.	Product Name	Price

Detailed Information

Developing Brain homeobox 2(DBX2) is a gene that encodes a protein involved in brain development and function. It is expressed primarily in the developing brain and is thought to play a role in the formation and function of synapses, as well as in neuronal migration and differentiation. Mutations in the DBX2 gene have been associated with a variety of neurological and psychiatric disorders, including autism spectrum disorder and schizophrenia. Research on DBX2 is ongoing and aims to better understand its role in brain development and disease.

Expression And Structure of DBX2

The DBX2 gene is expressed predominantly in the developing brain, with its expression declining as the brain matures. The DBX2 protein is involved in various aspects of brain development, including synapse formation and function, neuronal migration, and differentiation. Its expression is tightly controlled, with distinct patterns of expression in different brain regions and at different stages of development. The DBX2 gene is a member of the DBX gene family, which is conserved across various species. The DBX2 gene is approximately 200 kb in length and consists of five exons and four introns. The exons encode the DBX2 protein, while the introns are responsible for regulating gene expression. The DBX2 gene is located on chromosome 21, in the vicinity of the Down syndrome critical region. The structure of the DBX2 gene is complex, with multiple regulatory elements and several conserved domains.

DBX2-related Signaling Pathways

The DBX2 gene is involved in multiple signaling pathways that regulate brain development and function. It interacts with various transcription factors and signaling molecules to control the expression of target genes. One of the key signaling pathways in which DBX2 is involved is the Wnt signaling pathway, which plays a crucial role in synapse formation and neuronal migration. DBX2 also interacts with the Notch signaling pathway, which is involved in neuronal differentiation and synaptic plasticity. Other signaling pathways that DBX2 is associated with include the ERK/MAPK signaling pathway and the calcium signaling pathway. These interactions contribute to the diverse functions of DBX2 in brain development and disease.

Figure 1. Pathways involved in DBX2

Diseases And DBX2

Developing Brain homeobox 2 (DBX2) is a gene that plays a crucial role in brain development and has been implicated in various psychiatric disorders. This gene belongs to the homeobox family, which is responsible for regulating cell fate and spatial organization during embryonic development. Mutations in the DBX2 gene have been associated with several mental health conditions, including schizophrenia, bipolar disorder, and autism spectrum disorder. DBX2 is involved in the regulation of neuronal differentiation, synaptic plasticity, and neurotransmitter signaling. Abnormalities in these processes can lead to impaired cognitive function and behavioral abnormalities, which are hallmarks of psychiatric disorders. Moreover, DBX2 expression has been found to be altered in the brains of patients with mental health conditions, further supporting its role in these disorders.

References:

Lupo, Giuseppe et al. "Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline." Aging cell vol. 17,3 (2018): e12745. doi:10.1111/acel.12745
Giuliani, Andrea et al. "Dbx2, an Aging-Related Homeobox Gene, Inhibits the Proliferation of Adult Neural Progenitors." Stem cell reviews and reports, 10.1007/s12015-023-10600-7. 22 Aug. 2023, doi:10.1007/s12015-023-10600-7

Quick Inquiry

Interested in learning more?

Contact us today for a free consultation with the scientific team and discover how Creative Biogene can be a valuable resource and partner for your organization.

Request a quote today!

Inquiry