Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-RI0019 | Human CHRNA2 Stable Cell Line-HEK293 | Inquiry |
| CSC-DC003131 | Panoply™ Human CHRNA2 Knockdown Stable Cell Line | Inquiry |
| CSC-DC004029 | Panoply™ Human DARC Knockdown Stable Cell Line | Inquiry |
| CSC-SC003131 | Panoply™ Human CHRNA2 Over-expressing Stable Cell Line | Inquiry |
| CSC-SC004029 | Panoply™ Human DARC Over-expressing Stable Cell Line | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| AD03713Z | Human CHRNA2 adenoviral particles | Inquiry |
| AD04587Z | Human DARC adenoviral particles | Inquiry |
| LV09009L | human CHRNA2 (NM_000742) lentivirus particles | Inquiry |
| LV10297L | human DARC (NM_002036) lentivirus particles | Inquiry |
| LV10298L | human DARC (NM_001122951) lentivirus particles | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| SHH263545 | shRNA set against Rat CHRNA2 (NM_133420.1) | Inquiry |
| SHG177247 | shRNA set against Rat Chrna2(NM_133420.1) | Inquiry |
| SHG177265 | shRNA set against Mouse Chrna2(NM_144803.2) | Inquiry |
| SHG177577 | shRNA set against Human CHRNA2(NM_000742.3) | Inquiry |
| SHH263537 | shRNA set against Human CHRNA2 (NM_000742.3) | Inquiry |
| SHH263541 | shRNA set against Mouse CHRNA2 (NM_144803.2) | Inquiry |
| SHH274593 | shRNA set against Human DARC (NM_002036.3) | Inquiry |
| SHW005321 | shRNA set against Chicken CHRNA2 (NM_204815) | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| OE-PNDC000291 | Human CHRNA2 Nanodisc | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| CDFR014019 | Rat Chrna2 cDNA Clone(NM_133420.1) | Inquiry |
| MiUTR1H-02142 | CHRNA2 miRNA 3'UTR clone | Inquiry |
| MiUTR1M-03019 | CHRNA2 miRNA 3'UTR clone | Inquiry |
| MiUTR1R-00981 | CHRNA2 miRNA 3'UTR clone | Inquiry |
| MiUTR3H-12997 | DARC miRNA 3'UTR clone | Inquiry |
| MiUTR3H-12998 | DARC miRNA 3'UTR clone | Inquiry |
| CDCB166796 | Chicken CHRNA2 ORF Clone (NM_204815) | Inquiry |
| CDCB187624 | Rabbit CHRNA2 ORF clone (XM_002709452.2) | Inquiry |
| CDCR047020 | Human CHRNA2 ORF clone (NM_000742.3) | Inquiry |
| CDCR381074 | Rat Chrna2 ORF Clone(NM_133420.1) | Inquiry |
| CDCR383130 | Mouse Chrna2 ORF Clone(NM_144803.2) | Inquiry |
| CDCS407721 | Human DARC ORF Clone (BC017817) | Inquiry |
The Duffy blood group antigen, also known as Duffy antigen receptor for chemokines (DARC), is a glycoprotein receptor that plays a significant role in human immunity and disease. Named after its discovery by the hematologist Terence Hamblin in 1950, the Duffy antigen was initially identified as a blood group system. Individuals can be classified as Duffy positive (Fy^a/b^+) or Duffy negative (Fy^a/b^-), based on the presence or absence of the Duffy antigen on red blood cells.
Duffy antigen receptor for chemokines (DARC) is known for its unique ability to bind a wide range of chemokines. Chemokines are small signaling proteins secreted by cells to attract immune cells to sites of infection, inflammation, or tissue damage.
The broad binding specificity of DARC allows it to interact with various chemokines, including those involved in immune responses, inflammation, and tissue repair. Through these interactions, DARC influences the movement and positioning of immune cells within the body. By binding and sequestering chemokines, DARC modulates the immune response, controlling the recruitment and activity of immune cells in different tissues and organs. This function not only contributes to normal immune responses but also has implications in various diseases, including inflammatory disorders and infections.
Beyond its blood group function, DARC is primarily recognized as a chemokine receptor, participating in immune responses and inflammation. DARC binds various chemokines, which are small signaling proteins involved in immune cell trafficking and activation. Through its interactions with chemokines, DARC influences the migration and localization of immune cells, playing a crucial role in the immune defense against pathogens and in inflammatory processes.
Duffy Antigen Receptor for Chemokines (DARC) plays a pivotal role in the context of malaria, a life-threatening infectious disease caused by Plasmodium parasites. Plasmodium vivax, a parasite causing malaria, relies on DARC for red blood cell invasion, and the absence of DARC in Duffy-negative individuals provides resistance against P. vivax malaria. Specifically, DARC serves as a receptor on red blood cells, facilitating the invasion of Plasmodium vivax, one of the malaria-causing parasites. Individuals lacking DARC expression, known as Duffy-negative individuals, exhibit a natural resistance to P. vivax malaria. The absence of DARC on the surface of red blood cells prevents the parasite from entering these cells, providing a unique genetic defense mechanism against this particular strain of malaria.
Interestingly, DARC has a unique feature; it lacks the G-protein signaling domain commonly found in other chemokine receptors. Due to this absence, DARC does not initiate typical intracellular signaling pathways upon chemokine binding. Instead, it acts as a "silent" receptor, sequestering chemokines and regulating their availability in the bloodstream. This sequestration function of DARC has implications in various diseases, including malaria.
References: