CD248

Official Full Name

CD248 molecule

Organism

Homo sapiens

GeneID

57124

Background

Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Predicted to be involved in cell migration. Predicted to act upstream of or within several processes, including fibroblast migration; lymph node development; and positive regulation of endothelial cell apoptotic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Feb 2025]

Synonyms

TEM1; CD164L1;

Protein Sequence

MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLATPRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQPASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDHQIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPVSPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV

Open

Disease

Colorectal cancer, Kaposi sarcoma, Melanoma, Neuroendocrine carcinoma, Sarcoma

Approved Drug

Clinical Trial Drug

2 +

Discontinued Drug

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Detailed Information

The CD248 gene, also known as Endosialin, encodes a transmembrane glycoprotein involved in physiological processes such as tissue development, tumor angiogenesis, and inflammation. Being a cell surface glycoprotein, CD248 is important for extracellular matrix (ECM) binding, motility, and tumor angiogenesis. Its expression is intimately related to normal developmental processes and also significantly influences tumor formation as well as several inflammatory disorders. The structure, function, expression, and involvement of the CD248 gene in illnesses will be thoroughly reviewed in this paper.

Structure and Function of the CD248 Gene

The CD248 gene is located on the q arm of chromosome 11 in humans and encodes a C-type lectin-like protein. Five extracellular domains—three epidermal growth factor (EGF) repeat sequences, one mucin-like region, then a transmembrane domain and a short cytoplasmic tail define CD248. Using its transmembrane domain, which serves on the cell surface, CD248 binds cells to the extracellular matrix (ECM). Calcium-binding and ECM-binding sites among other functional domains in the protein help CD248 to be involved in cellular motility, tumor angiogenesis, and ECM remodeling.

Figure 1 illustrates the structural features of the CD248 protein. Figure 1. CD248 protein structure. (Teicher BA, 2019)

Particularly in the tumor microenvironment, CD248 is thought to be quite critical for tumor angiogenesis. Through interactions with ECM elements like collagen and fibronectin, CD248 helps blood vessels around the tumor to develop. Furthermore, the EGF-like domains of the protein imply it could be involved in cell signaling through interactions with other proteins.

Role of CD248 in Tissue Development

The CD248 gene plays a critical role during embryonic development, particularly in the development of lymphoid tissues. Mostly in fibroblasts and perivascular cells, studies have shown that CD248 is abundantly expressed in lymphoid organs including the thymus, lymph nodes, and spleen. CD248 promotes the proliferation and migration of mesenchymal cells, therefore facilitating tissue remodeling and functional repair during the formation of lymphoid tissues. In adults, however, CD248 expression is generally restricted to certain organs, including the normal endometrial stroma and sometimes in fibroblasts.

Role of CD248 in Diseases

In cancer research, CD248 is under increasing interest as a possible tumor marker. Early research indicates that most malignant tumors—especially in sarcomas and certain carcinomas—have highly expressed CD248. CD248 promotes the migration and multiplication of endothelial cells in the tumor microenvironment during tumor angiogenesis. CD248 is therefore regarded as a therapeutic target in addition to a molecular marker for tumors. By helping to restrict tumor angiogenesis, targeting CD248 may assist in limiting tumor development and metastases.

Different disorders, including fibrotic diseases and tumor growth, are connected to abnormal expression of the CD248 gene. For example, strongly expressed in synovial tissue of rheumatoid arthritis and psoriatic arthritis, CD248 suggests a possible function in inflammatory reactions and tissue remodeling. In these disorders, CD248 may control the activation of fibroblasts and smooth muscle cells in blood arteries, therefore promoting joint degeneration and ongoing inflammation.

Furthermore, CD248 is quite critical for bone metabolism. Presumably because of higher osteoblast activity, studies have demonstrated that mice devoid of CD248 display notably better mechanical characteristics and bone quality. Therapeutic approaches aiming at CD248 might therefore provide new paths for treating conditions like rheumatoid arthritis.

Clinical Applications and Research Prospects of CD248

Given its significant role in tumors and inflammatory diseases, CD248 has become a potential target for cancer immunotherapy and targeted treatment. Future cancer treatments may depend much on developing antibodies or inhibitors aimed at CD248. Furthermore, the function of CD248 as a biomarker is quite important for the diagnosis and prognosis of diseases. For instance, its interactions with Mac-2 BP/90K are a possible prognostic biomarker for lung and breast malignancies.

References:

Teicher BA. CD248: A therapeutic target in cancer and fibrotic diseases. Oncotarget. 2019 Jan 29;10(9):993-1009.
Bartis D, Crowley LE, D'Souza VK, et al. Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis. BMC Pulm Med. 2016 Apr 14;16(1):51.

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