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Representative Data of Multiple Cardiac Screening Panels


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Representative Data of Multiple Cardiac Screening Panels

With years of development, Creative Biogene now has the expertise and ability in offering you unique preclinical services in the cardiac safety assays to better predict the proarrhythmic liability of your test compounds. Representative data of automated electrophysiology screening against multiple cardiac screen panels (including hERG, NaV1.5, CaV1.2, Kir2.1, KV1.5 etc) are shown below:

Channel hERG
Gene symbol KCNH2
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor E 4031, cisapride, dofetilide
Target Antiarrhythmia, QT-prolongation, Torsade de Pointe (Tdp)

Representative Data of Multiple Cardiac Screening Panels


Channel NaV1.5
Gene symbol SCN5A
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor TTX, lidocaine, decaine, flecainide
Target Brugada syndrome, long QT syndrome, progressive cardiac conduction disease, dilated cardiomyopathy, sick sinus syndrome and atrial fibrillation

Representative Data of Multiple Cardiac Screening Panels


Channel Cav1.2
Gene symbol CACNA1C
Species Human
Host cell CHO
Method Whole cell patch clamp
Reference inhibitor Nifedipine, verapamil
Target Timothy syndrome, long QT syndrome, pain, epilepsy, hypertension, stroke, arrhythmia, autism

Representative Data of Multiple Cardiac Screening Panels


Channel Kir2.1
Gene symbol KCNJ2
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor BaCl2
Target Long QT prolongation

Representative Data of Multiple Cardiac Screening Panels


Channel Kv1.5
Gene symbol KCNA5
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor 4-AP, quinidine
Target Atrial fibrillation

Representative Data of Multiple Cardiac Screening Panels


Channel KvLQT/mink
Gene symbol KCNQ1/KCNE1
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor Chromanol 293B
Target Atrial fibrillation, long QT syndrome

Representative Data of Multiple Cardiac Screening Panels

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