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Representative Data of Multiple Cardiac Screening Panels
With years of development, Creative Biogene now has the expertise and ability in offering you unique preclinical services in the cardiac safety assays to better predict the proarrhythmic liability of your test compounds. Representative data of automated electrophysiology screening against multiple cardiac screen panels (including hERG, NaV1.5, CaV1.2, Kir2.1, KV1.5 etc) are shown below:
| Channel | hERG |
| Gene symbol | KCNH2 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | E 4031, cisapride, dofetilide |
| Target | Antiarrhythmia, QT-prolongation, Torsade de Pointe (Tdp) |
| Channel | NaV1.5 |
| Gene symbol | SCN5A |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | TTX, lidocaine, decaine, flecainide |
| Target | Brugada syndrome, long QT syndrome, progressive cardiac conduction disease, dilated cardiomyopathy, sick sinus syndrome and atrial fibrillation |
| Channel | Cav1.2 |
| Gene symbol | CACNA1C |
| Species | Human |
| Host cell | CHO |
| Method | Whole cell patch clamp |
| Reference inhibitor | Nifedipine, verapamil |
| Target | Timothy syndrome, long QT syndrome, pain, epilepsy, hypertension, stroke, arrhythmia, autism |
| Channel | Kir2.1 |
| Gene symbol | KCNJ2 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | BaCl2 |
| Target | Long QT prolongation |
| Channel | Kv1.5 |
| Gene symbol | KCNA5 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | 4-AP, quinidine |
| Target | Atrial fibrillation |
| Channel | KvLQT/mink |
| Gene symbol | KCNQ1/KCNE1 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | Chromanol 293B |
| Target | Atrial fibrillation, long QT syndrome |
