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Representative Data for Sodium Channels


With years of experience and expertise in ion channel screening & profiling filed, Creative Biogene can provide the most professional...

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Representative Data for Sodium Channels

With years of experience and expertise in ion channel screening & profiling filed, Creative Biogene can provide the most professional and outstanding ion channel service with various sodium channels to efficiently save your time of your drug discovery project.

Representative data of automated electrophysiology screening against multiple sodium channels are shown below:

Channel Nav1.1
Gene symbol SCN1A
Species Human
Host cell CHO
Method Whole cell patch clamp
Reference inhibitor TTX, lidocaine, decaine
Target Pain, Epilepsy, Anxiety, Depression, Degenerate Diseases, Dravet syndrome, West syndrome

Channel Nav1.2
Gene symbol SCN2A
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor TTX, lidocaine, decaine
Target Pain, Seizure, Epilepsy, Anxiety, Depression, Degenerative Diseases

Channel Nav1.3
Gene symbol SCN3A
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor TTX, lidocaine, decaine
Target Pain, Epilepsy, Anxiety, Depression

Channel Nav1.5
Gene symbol SCN5A
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor TTX, lidocaine, decaine
Target Brugada syndrome, long QT syndrome, progressive cardiac conduction disease, dilated cardiomyopathy, sick sinus syndrome, atrial fibrillation

Channel Nav1.6
Gene symbol SCN8A
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor TTX, lidocaine, decaine
Target Epilepsy, Degenerative Diseases

Channel Nav1.7
Gene symbol SCN9A
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor TTX, lidocaine, decaine
Target Pain, Anxiety, Depression, Erythromelalgia

Channel Nav1.8
Gene symbol SCN10A
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor TTX, A803467
Target Pain, Anxiety, Depression

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