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With years of experience and expertise in ion channel screening & profiling filed, Creative Biogene can provide the most professional and outstanding ion channel service with various sodium channels to efficiently save your time of your drug discovery project.
Representative data of automated electrophysiology screening against multiple sodium channels are shown below:
| Channel | Nav1.1 |
| Gene symbol | SCN1A |
| Species | Human |
| Host cell | CHO |
| Method | Whole cell patch clamp |
| Reference inhibitor | TTX, lidocaine, decaine |
| Target | Pain, Epilepsy, Anxiety, Depression, Degenerate Diseases, Dravet syndrome, West syndrome |
| Channel | Nav1.2 |
| Gene symbol | SCN2A |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | TTX, lidocaine, decaine |
| Target | Pain, Seizure, Epilepsy, Anxiety, Depression, Degenerative Diseases |
| Channel | Nav1.3 |
| Gene symbol | SCN3A |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | TTX, lidocaine, decaine |
| Target | Pain, Epilepsy, Anxiety, Depression |
| Channel | Nav1.5 |
| Gene symbol | SCN5A |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | TTX, lidocaine, decaine |
| Target | Brugada syndrome, long QT syndrome, progressive cardiac conduction disease, dilated cardiomyopathy, sick sinus syndrome, atrial fibrillation |
| Channel | Nav1.6 |
| Gene symbol | SCN8A |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | TTX, lidocaine, decaine |
| Target | Epilepsy, Degenerative Diseases |
| Channel | Nav1.7 |
| Gene symbol | SCN9A |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | TTX, lidocaine, decaine |
| Target | Pain, Anxiety, Depression, Erythromelalgia |
| Channel | Nav1.8 |
| Gene symbol | SCN10A |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | TTX, A803467 |
| Target | Pain, Anxiety, Depression |
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