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Representative Data for Potassium Channels

With years of experience and expertise in ion channel screening & profiling filed, Creative Biogene can provide the most professional and outstanding ion channel service with various potassium channels to efficiently save your time of your drug discovery project.

Representative data of automated electrophysiology screening against multiple potassium channels are shown below:

Channel Kir2.1
Gene symbol KCNJ2
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor BaCl2
Target Resting potential, Long QT prolongation

Channel Kir3.1/Kir3.4
Gene symbol KCNJ3/KCNJ5
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor BaCl2
Target Atrial fibrillation

Channel Kv1.5
Gene symbol KCNA5
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor 4-AP, quinidine
Target Atrial fibrillation

Channel KvLQT/mink
Gene symbol KCNQ1/KCNE1
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor Chromanol 293B
Target Atrial fibrillation, long QT syndrome

Channel Kv7.2/Kv7.3
Gene symbol KCNQ2/ KCNQ3
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor Retigabine
Target Epilepsy

Channel Kv7.4
Gene symbol KCNQ4
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor ML213
Target Cochlea

Channel hERG
Gene symbol KCNH2
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor E 4031, cisapride, dofetilide
Target Antiarrhythmia, QT-prolongation, Torsade de Pointe (Tdp)

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