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With years of experience and expertise in ion channel screening & profiling filed, Creative Biogene can provide the most professional and outstanding ion channel service with various potassium channels to efficiently save your time of your drug discovery project.
Representative data of automated electrophysiology screening against multiple potassium channels are shown below:
| Channel | Kir2.1 |
| Gene symbol | KCNJ2 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | BaCl2 |
| Target | Resting potential, Long QT prolongation |
| Channel | Kir3.1/Kir3.4 |
| Gene symbol | KCNJ3/KCNJ5 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | BaCl2 |
| Target | Atrial fibrillation |
| Channel | Kv1.5 |
| Gene symbol | KCNA5 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | 4-AP, quinidine |
| Target | Atrial fibrillation |
| Channel | KvLQT/mink |
| Gene symbol | KCNQ1/KCNE1 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | Chromanol 293B |
| Target | Atrial fibrillation, long QT syndrome |
| Channel | Kv7.2/Kv7.3 |
| Gene symbol | KCNQ2/ KCNQ3 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | Retigabine |
| Target | Epilepsy |
| Channel | Kv7.4 |
| Gene symbol | KCNQ4 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | ML213 |
| Target | Cochlea |
| Channel | hERG |
| Gene symbol | KCNH2 |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | E 4031, cisapride, dofetilide |
| Target | Antiarrhythmia, QT-prolongation, Torsade de Pointe (Tdp) |
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