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Representative Data for Calcium Channels

With years of experience and expertise in ion channel screening & profiling filed, Creative Biogene can provide the most professional and outstanding ion channel service with various calcium channels to efficiently save your time of your drug discovery project.

Representative data of automated electrophysiology screening against multiple calcium channels are shown below:

Channel Cav1.2
Gene symbol CACNA1C
Species Human
Host cell CHO
Method Whole cell patch clamp
Reference inhibitor Nifedipine, verapamil
Target Timothy syndrome, long QT syndrome, Pain, epilepsy, hypertension, stroke, arrhythmia, Autism

Channel Cav2.1
Gene symbol CACNA1A
Species Human
Host cell CHO
Method Whole cell patch clamp
Reference inhibitor Cadmium, w-agatoxin
Target Migraine, seizure and ataxia syndromes

Channel Cav2.2
Gene symbol CACNA1B
Species Human
Host cell CHO
Method Whole cell patch clamp
Reference inhibitor Cadmium, w-conotoxin, Huwentoxin-1
Target Pain, spinal cord injury, kleefstra syndrome

Channel Cav3.2
Gene symbol CACNA1H
Species Human
Host cell HEK293
Method Whole cell patch clamp
Reference inhibitor Nifedipine, verapamil, NiCl
Target convulsion

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