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With years of experience and expertise in ion channel screening & profiling filed, Creative Biogene can provide the most professional and outstanding ion channel service with various calcium channels to efficiently save your time of your drug discovery project.
Representative data of automated electrophysiology screening against multiple calcium channels are shown below:
| Channel | Cav1.2 |
| Gene symbol | CACNA1C |
| Species | Human |
| Host cell | CHO |
| Method | Whole cell patch clamp |
| Reference inhibitor | Nifedipine, verapamil |
| Target | Timothy syndrome, long QT syndrome, Pain, epilepsy, hypertension, stroke, arrhythmia, Autism |
| Channel | Cav2.1 |
| Gene symbol | CACNA1A |
| Species | Human |
| Host cell | CHO |
| Method | Whole cell patch clamp |
| Reference inhibitor | Cadmium, w-agatoxin |
| Target | Migraine, seizure and ataxia syndromes |
| Channel | Cav2.2 |
| Gene symbol | CACNA1B |
| Species | Human |
| Host cell | CHO |
| Method | Whole cell patch clamp |
| Reference inhibitor | Cadmium, w-conotoxin, Huwentoxin-1 |
| Target | Pain, spinal cord injury, kleefstra syndrome |
| Channel | Cav3.2 |
| Gene symbol | CACNA1H |
| Species | Human |
| Host cell | HEK293 |
| Method | Whole cell patch clamp |
| Reference inhibitor | Nifedipine, verapamil, NiCl |
| Target | convulsion |
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