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PV-Based Viral Entry Inhibitor Development

-What is Viral Entry Inhibitor?

By definition, viral entry inhibitor refers to the class of compounds that interfere with the process of viral fusion with host cells for infection. First tested with HIV as proving ground, viral entry inhibitor has been rapidly growing as one of the most promising research topics in antiviral therapies while expanding its applications to other emerging viruses such as MERS-CoV, Ebola virus, and Hepatitis C virus (HCV).

PV-Based Viral Entry Inhibitor DevelopmentFig 1. Stages of HIV-1 viral entry process (Didigu & Doms, 2012).

-What is the application of Viral Entry Inhibitors?

The viral entry process has been broken down into 7 targetable elements for inhibitor development:

1. General viral entry inhibitors;

2. High-throughput Screening (HTS) for inhibitor candidates;

3. Viral attachment inhibitors;

4. Receptor engagement inhibitors;

5. Internalization inhibitors;

6. Glycoprotein activation inhibitors;

7. Membrane fusion inhibitors.

-What are the advantages of PV-based Viral Entry Inhibitor development?

As the very first step of infection process, viral entry could be interrupted at relatively low risk for damaging off-target effects, making them potentially safer medications to administrate. Combination of PV-based systems with viral entry inhibitor development allows broad-spectrum antivirals to be discovered and screened through HTS, making the process more cost-effective and rapid.

-What is offered by Creative Biogene?

1. Transfected stable cell line establishment for antiviral screening;

2. Viral entry inhibitor development for specific targets.

At Creative Biogene, not only do we provide our clients with top-quality of inhibitor developmental services, but we also offer fully customized solution should your research requires specific items/services that have not been included. For any inquiries, please feel free to contact us at 1-631-626-9181 or email: , our highly experienced technical support scientists are more than happy to discuss over details of your research plan and offer the best solution catered specifically to your needs.

-Why Creative Biogene?

Creative Biogene has rich history of success and commitment to providing our clients with the best service using only state-of-the-art equipment and finest materials. Coming from world renowned institutions around the globe, researchers of our laboratory team are well-trained and highly experienced with the devotion and dedication to fulfill any requirements by our clients to satisfactory. At Creative Biogene, industry-leading PV customization service is offered to all of our clients at competitive pricing with rapid turnaround time, ensuring an easy and trouble-free start of your research.

Reference:

  1. Didigu C. & Doms R. W. (2012), 'Novel Approaches to Inhibit HIV Entry', Virus, 4(2): 309-24.
For research use only. Not intended for any clinical use.