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Human CACNA1A/CACNB4/CACNA2D1 Stable Cell Line-CHO

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Cat.No.
CSC-RI0071
Background
The human CACNA1A gene encodes the pore-forming subunit of voltage-gated P/Q-type Ca2+ channels. Co-expression with the beta 4 and alpha2delta1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav2.1 channels, widely distributed in neurons, are therapeutic targets in treatment of inflammatory pain.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO
Ship
Dry ice
Gene Information
Official Symbol
CACNB4
Synonyms
CACNB4; CAB4; CACNLB4; EA5; EIG9; EJM; EJM4; EJM6; calcium channel, voltage-dependent, beta 4 subunit; calcium channel voltage-dependent subunit beta 4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; voltage-dependent L-type calcium channel subunit beta-4
Gene ID
MIM
UniProt ID
O00305
Chromosome Location
2q22-q23
Pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC); Axon guidance; Cardiac muscle contraction; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels; Developmental Biology; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM);
Function
contributes_to high voltage-gated calcium channel activity; protein binding; contributes_to voltage-gated calcium channel activity

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