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Human CACNA1B Stable Cell Line-HEK293

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Cat.No.
CSC-RI0001
Background
CACNA1B is a voltage-gated calcium channel alpha subunit. It is expressed almost exclusively in neurons typically located at high densities in presynaptic terminals. Opening of these channels enables the rapid influx of the extracellular Ca2+, triggering exocytotic vesicle fusion with terminal membranes and subsequent neurotransmitter release. Evidence suggests that Cav2.2 channels have a fundamental role in instigating increased excitability and neurotransmitter release in various pain syndromes. The link between CACNA1B and pain neurotransmission in humans has been further vindicated by the effectiveness of PrialtR (ziconotide), a synthetic version of omega-conotoxin MVIIA, in treating severe chronic pain.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
CACNA1B
Synonyms
CACNA1B; calcium channel, voltage-dependent, N type, alpha 1B subunit; CACNL1A5; voltage-dependent N-type calcium channel subunit alpha-1B; CACNN; Cav2.2; calcium channel, N type; brain calcium channel III; Cav2.2 voltage-gated Ca2+ channel; calcium channel alpha12.2 subunit; calcium channel, L type, alpha-1 polypeptide; voltage-gated calcium channel alpha subunit Cav2.2; voltage-gated calcium channel subunit alpha Cav2.2; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, alpha 1B subunit, N type; BIII;
Gene ID
MIM
UniProt ID
Q00975
Chromosome Location
9q34
Pathway
Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem;
Function
ATP binding; ion channel activity; nucleotide binding; protein C-terminus binding; protein binding; voltage-gated calcium channel activity; voltage-gated ion channel activity;

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