Recombinant Human HER3 (C-6His)

Name: Recombinant Human HER3 (C-6His)
SKU: RP00020

Cat.No. : RP00020 Tag: C-6His

Expressed Region: Ser20-Thr643 Expression System: Human Cell

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Product Details

Target Information

Cat. No.	RP00020
Description	The Recombinant Human HER3 (C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Ser20-Thr643 with a 6His tag at the C terminus.
Species	Human
Tag	C-6His
Mol. Weight	69.5 KDa
Expressed Region	Ser20-Thr643
Expression System	Human Cell
Format	Liquid
Formulation	Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH7.4.
Conjugate	Unconjugated
Endotoxin Level	< 1 EU/µg of protein by LAL method
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.

Target Gene	HER3
Background	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Synonyms	Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ERBB3; HER3

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