DENV DENV-NS5A ORF clone (AF038403.1)

Name: DENV DENV-NS5A ORF clone (AF038403.1)
SKU: CDCB156810
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCB156810

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Product Information

Gene Information

Cat. No.	CDCB156810
Description	ORF Clone of Homo sapiens ORF Clone of DENV-2 (strain New Guinea C) NS5A DNA. DNA. Identical with the Gene Bank Ref. ID sequence AF038403.1 (7570..10269), corresponding to amino acid sequence AAC59275.1 (aa 2492-3391).
Gene Abbr	DENV-NS5A
Species	DENV
ORF Size	2700 bp
Sequence	GGAACTGGCA ACATAGGAGA GACGCTTGGA GAGAAATGGA AAAGCCGATT GAACGCATTG GGGAAAAGTG AATTCCAGAT CTACAAGAAA AGTGGAATCC AGGAAGTGGA TAGAACCTTA GCAAAAGAAG GCATTAAAAG AGGAGAAACG GACCATCACG CTGTGTCGCG AGGCTCAGCA AAACTGAGAT GGTTCGTCGA GAGAAATATG GTCACACCAG AAGGGAAAGT AGTGGACCTC GGTTGCGGCA GAGGAGGCTG GTCATACTAT TGTGGGGGAC TAAAGAATGT AAGAGAAGTC AAAGGCCTGA CAAAAGGAGG ACCAGGACAT GAAGAACCCA TCCCCATGTC AACATATGGG TGGAATCTAG TACGTCTTCA AAGTGGAGTT GACGTTTTCT TCACTCCGCC AGAAAAGTGT GACACATTGT TGTGTGACAT AGGGGAGTCG TCACCAAATC CCACGGTAGA AGCAGGACGA ACACTCAGAG TCCTTAACTT AGTGGAAAAT TGGTTGAACA ACAACACCCA ATTTTGCATA AAGGTTCTCA ACCCATACAT GCCCTCAGTC ATAGAAAAAA TGGAAGCACT ACAAAGGAAA TATGGAGGAG CCTTAGTGAG GAATCCACTC TCACGAAACT CCACACATGA GATGTACTGG GTATCCAATG CCTCCGGGAA CATAGTGTCA TCAGTGAACA TGATTTCAAG GATGTTGATC AACAGATTCA CAATGAGACA CAAGAAAGCC ACTTACGAGC CAGATGTAGA CCTCGGAAGC GGAACCCGCA ACATCGGAAT TGAAAGTGAG ATACCAAACC TAGACATAAT CGGGAAAAGA ATAGAAAAAA TAAAACAAGA GCATGAAACA TCATGGCACT ATGACCAAGA CCACCCATAC AAAACGTGGG CTTACCATGG CAGCTATGAA ACAAAACAAA CTGGATCAGC ATCATCCATG GTGAACGGAG TGGTCAGACT GCTGACAAAA CCTTGGGACG TCGTCCCCAT GGTGACACAG ATGGCAATGA CAGACACGAC TCCATTTGGA CAACAGCGCG TTTTTAAAGA AAAAGTGGAC ACGAGAACCC AAGAACCGAA AGAAGGCACA AAGAAACTAA TGAAAATCAC GGCAGAGTGG CTTTGGAAAG AACTAGGGAA GAAAAAGACA CCTAGGATGT GCACTAGAGA AGAATTCACA AGAAAGGTGA GAAGCAATGC AGCCTTGGGG GCCATATTCA CTGATGAGAA CAAGTGGAAG TCGGCACGTG AGGCTGTTGA AGATAGTAGG TTTTGGGAGC TGGTTGACAA GGAAAGGAAT CTCCATCTTG AAGGAAAGTG TGAAACATGT GTGTATAACA TGATGGGAAA AAGAGAGAAG AAGCTAGGGG AGTTCGGCAA GGCAAAAGGC AGCAGAGCCA TATGGTACAT GTGGCTTGGA GCACGCTTCT TAGAGTTTGA AGCCCTAGGA TTCTTGAATG AAGATCACTG GTTCTCCAGA GAGAACTCCT TGAGTGGAGT GGAAGGAGAA GGGCTGCACA AGCTAGGTTA CATTTTAAGA GACGTGAGCA AGAAAGAGGG AGGAGCAATG TATGCCGATG ACACCGCAGG ATGGGACACA AGAATCACAC TAGAAGACCT AAAAAATGAA GAAATGGTAA CAAACCACAT GGAAGGAGAA CACAAGAAAC TAGCCGAGGC CATTTTCAAA TTAACGTACC AAAACAAGGT GGTGCGTGTG CAAAGACCAA CACCAAGAGG CACAGTAATG GATATCATAT CGAGAAGAGA CCAAAGAGGT AGTGGACAAG TTGGTACCTA TGGACTCAAT ACTTTCACCA ATATGGAAGC CCAACTAATC AGACAGATGG AGGGAGAAGG AGTCTTCAAA AGCATTCAGC ACCTGACAGT CACAGAAGAA ATCGCCGTGC AAAACTGGTT AGCAAGAGTA GGGCGCGAAA GGTTATCAAG AATGGCCATC AGTGGAGATG ATTGTGTTGT GAAACCTTTA GATGACAGGT TCGCAAGCGC TTTAACAGCT CTAAATGACA TGGGAAAGGT TAGGAAAGAC ATACAACAAT GGGAACCTTC AAGAGGATGG AACGATTGGA CACAAGTGCC CTTCTGTTCA CACCATTTCC ATGAGTTAAT CATGAAAGAC GGCCGCGTAC TTGTAGTTCC ATGCAGAAAC CAAGATGAAC TGATTGGTAG AGCCCGAATT TCCCAAGGAG CTGGGTGGTC TTTGCGAGAG ACGGCCTGTT TGGGGAAGTC CTACGCCCAA ATGTGGAGCT TGATGTACTT CCACAGACGT GACCTCAGGC TGGCGGCTAA TGCTATTTGC TCGGCAGTCC CATCACATTG GGTTCCAACA AGTAGAACAA CCTGGTCCAT ACACGCCAAA CATGAATGGA TGACAACGGA AGACATGCTG ACAGTCTGGA ACAGGGTGTG GATTCAAGAA AACCCATGGA TGGAAGACAA AACTCCAGTG GAATCATGGG AGGAAATCCC ATACTTGGGG AAAAGAGAAG ACCAATGGTG CGGCTCATTG ATTGGGCTAA CAAGCAGGGC CACCTGGGCA AAGAACATCC AAACAGCAAT AAATCAAGTT AGATCCCTTA TAGGC

Target Gene

DENV-NS5A

Background

The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]

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