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MicroRNAs (miRNAs), 18–24 nt RNA molecules, regulate mRNA stability and translation. They impact cellular processes and play a crucial role in cancer development. Recombinant adenoviruses provide efficient gene delivery to mammalian cells without genomic integration, excelling in expressing proteins and delivering microRNA for translational repression, making them exceptional for in vivo applications. Creative Biogene offers adenovirus miRNAs with comprehensive human genome coverage. Our premade adenovirus-delivered miRNAs provide ready-to-use, efficient gene silencing. For time-saving solutions, choose from a variety of hsa-miRNAs integrated into premade adenovirus. Additionally, we offer custom miRNA adenovirus construction and production services to accommodate your research budgets.
Benefits of Our microRNA Adenovirus Particles
Browse All microRNA Adenovirus Particles
miRNA adenovirus particles offer extensive coverage of the human genome. This innovative solution facilitates in-depth exploration of miRNA functions, gene silencing mechanisms, and disease modeling. With a commitment to advancing research, Creative Biogene ensures ready-to-use, high-quality adenovirus microRNAs, delivering a seamless experience for researchers seeking reliable and comprehensive tools in the field of functional genomics. Utilize Creative Biogene's microRNA Adenovirus Particles to accomplish the following:
Case Study 1
In obesity-associated chronic inflammation, constraining subcutaneous white adipose tissue (WAT) expansion accelerates insulin resistance and type 2 diabetes. The researchers correlate miR-30a expression in subcutaneous WAT with insulin sensitivity in obese mice and humans. To test if restoring miR-30a enhances insulin sensitivity, adenovirus (Adv) expressing miR-30a was injected into diabetic mice's subcutaneous fat pad. Exogenous miR-30a expression in obese mice's WAT improved insulin sensitivity, reduced hepatic fat deposition, and decreased WAT inflammation. Proteomic and RNA-Seq analyses revealed miR-30a targeting STAT1, limiting interferon-gamma (IFN-γ) activity, preventing WAT restriction, and insulin sensitivity reduction.
Figure 1. DIO mice received subcutaneous injections of Adv expressing
miR-30a or GFP. Robust miR-30a expression, confirmed by GFP reporting, is significantly elevated in inguinal WAT.
(Koh, E. H., et al., 2018).
Case Study 2
Follicular development in ovaries is complex, impacting fertility. The researchers, using RNA sequencing, in situ hybridization, and in vitro/ or in vivo models, explored miR-338-3p's role. Elevated miR-338-3p is observed in ovarian insufficiency patients, affecting granulosa cell proliferation, estradiol production, and early follicular development. MiR-338-3p's involvement in TGF-β-dependent regulation is suggested. In vivo, miR-338-3p disrupts oocyte mitochondrial membrane potential and estrous cycles. This research informs on miR-338-3p's role in abnormal follicular development, aiding infertility diagnosis and treatment.
Figure 2. Neonatal D1 and D4 female CD1 (ICR) mice underwent cervical
dislocation. Ovaries were isolated, categorized into three groups, and cultured. Adenoviral vectors (adv-EGFP or
adv-miR-338-3p) were transfected. After 48 h, ovaries were fixed and subjected to HE staining. (Xu Z, et
al., 2023).
Q: What is the primary purpose of MicroRNA Adenovirus Particles in molecular research?
A: MicroRNA Adenovirus Particles are designed for the delivery and modulation of microRNA expression, allowing researchers to investigate the functional implications of specific microRNAs in cellular processes.
Q: How are these adenovirus particles engineered to target specific microRNAs?
A: MicroRNA Adenovirus Particles can be customized to carry and express specific microRNA sequences, providing a targeted approach for the functional study of individual microRNAs.
Q: What advantages do these adenovirus particles offer in studying microRNA function compared to other methods?
A: Adenovirus particles ensure efficient delivery of microRNAs into a wide range of cell types. Researchers can modulate the expression of specific microRNAs, allowing precise control over experimental conditions.
Q: In what experimental scenarios are MicroRNA Adenovirus Particles particularly valuable?
A: These particles are valuable in experiments where researchers aim to elucidate the roles of specific microRNAs in processes such as cell differentiation, proliferation, apoptosis, and disease development.
Q: How can researchers control the level and duration of microRNA expression using these particles?
A: Researchers have control over the level and duration of microRNA expression by adjusting viral titers and optimizing experimental conditions, allowing for temporal and dose-dependent regulation.
| Cat.No. | Product Name | Price |
|---|---|---|
| AD00428W | Human mir1231 Adenovirus Particles | Inquiry |
| AD00429W | Human mir3680-5p Adenovirus Particles | Inquiry |
| AD00430W | Human mir3680-2 Adenovirus Particles | Inquiry |
| AD00431W | Human mir3680-3p Adenovirus Particles | Inquiry |
| AD00432W | Human mir3680-2 Adenovirus Particles | Inquiry |
| AD00433W | Human mir582 Adenovirus Particles | Inquiry |
| AD00434W | Human mir582 Adenovirus Particles | Inquiry |
| AD00435W | Human mir487b Adenovirus Particles | Inquiry |
| AD00436W | Human mir652 Adenovirus Particles | Inquiry |
| AD00437W | Human mir652 Adenovirus Particles | Inquiry |
| AD00438W | Human mir5704 Adenovirus Particles | Inquiry |
| AD00439W | Human mir558 Adenovirus Particles | Inquiry |
| AD00440W | Human mir455 Adenovirus Particles | Inquiry |
| AD00441W | Human mir455 Adenovirus Particles | Inquiry |
| AD00442W | Human mir4290 Adenovirus Particles | Inquiry |
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