IKAROS family zinc finger 1 - Creative Biogene

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IKZF1

Official Full Name

IKAROS family zinc finger 1

Organism

Homo sapiens

GeneID

10320

Background

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

Synonyms

IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452;

Cat.No.	Product Name	Price
CSC-DC007523	Panoply™ Human IKZF1 Knockdown Stable Cell Line	Inquiry
CSC-SC007523	Panoply™ Human IKZF1 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
CSC-DC007523	Panoply™ Human IKZF1 Knockdown Stable Cell Line	Inquiry
CSC-SC007523	Panoply™ Human IKZF1 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
CSC-DC007523	Panoply™ Human IKZF1 Knockdown Stable Cell Line	Inquiry
CSC-SC007523	Panoply™ Human IKZF1 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
CSC-DC007523	Panoply™ Human IKZF1 Knockdown Stable Cell Line	Inquiry
CSC-SC007523	Panoply™ Human IKZF1 Over-expressing Stable Cell Line	Inquiry

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