Official Full Name

ubiquitin-like modifier activating enzyme 1

Background

Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which targets a protein for degradation via a proteasome. This covalent attachment of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Many processes such as cell division, immune responses and embryonic development are also regulated by post-transcriptional modification by ubiquitin and ubiquitin-like proteins.

Synonyms

UBA1; ubiquitin-like modifier activating enzyme 1; A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; POC20; SMAX2; UBA1A; UBE1X; MGC4781; ubiquitin-like modifier-activating enzyme 1; zgc:66143; wu:fa01e08; wu:fb30f01; wu:fi21c11; wu:fj14g11; fb30f01; ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)