Official Full Name

selectin L

Background

L-Selectin encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, plus two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, which facilitates their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene

Synonyms

CD62 antigen like family member L; CD62L; CD62L antigen; gp90 MEL; hLHRc; LAM 1; LAM1; LECAM1; Leu 8; LEU8; Leukocyte adhesion molecule 1; Leukocyte endothelial cell adhesion molecule 1; Leukocyte surface antigen Leu 8; LNHR; LSEL; Lyam 1; LYAM1; Lymph node homing receptor; lymphocyte adhesion molecule 1; pln homing receptor; PLNHR; selectin L; SELL; TQ1; L-selectin; LNHR, LYAM1, lymphocyte adhesion molecule 1; gp90-MEL; leukocyte surface antigen Leu-8; CD62 antigen-like family member L; leukocyte-endothelial cell adhesion molecule 1; Ly-22; Ly-m22; Lyam-1; LECAM-1; AI528707; selenoprotein L