Official Full Name

ribosomal protein S6 kinase, 90kDa, polypeptide 3

Background

The RSK or 90-kDa ribosomal S6 kinase family of proteins isa group of highly conserved Ser/Thr kinases that regulatediverse cellular processes during the growth factor mediatedstimulation of cell proliferation, survival anddifferentiation (1). In mammals, four RSK genes havebeen identified (RSK1, RSK2, RSK3 and RSK4), and the RSKisoforms are composed of two distinct and functionalkinase domains that are activated in a sequentialmanner by a series of phosphorylation events. RSKs aredownstream effectors of the Ras-extracellular signal regulatedkinase (ERK)/mitogen-activated protein kinase(MAPK) signalling cascade.

Synonyms

RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; CLS, Coffin Lowry syndrome , mental retardation, X linked 19 , MRX19, ribosomal protein S6 kinase, 90kD, polypeptide 3; ribosomal protein S6 kinase alpha-3; HU 3; RSK; RSK2; RSK-2; p90-RSK 3; MAPKAPK-1b; S6K-alpha-3; MAPKAP kinase 1b; ribosomal S6 kinase 2; MAPK-activated protein kinase 1b; insulin-stimulated protein kinase 1; MAP kinase-activated protein kinase 1b; CLS; HU-3; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3