Official Full Name

MAX dimerization protein 1

Background

This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Synonyms

MXD1; MAX dimerization protein 1; MAD; bHLHc58; MAD1; max dimerizer 1; MAX-binding protein; antagonizer of myc transcriptional activity; MGC104659; MAD, MAD1, BHLHC58