Official Full Name

mitochondrial ribosomal protein L2

Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q.

Synonyms

MRPL2; mitochondrial ribosomal protein L2; 39S ribosomal protein L2, mitochondrial; CGI 22; MRP L14; RPML14; 39S ribosomal protein L2, mitochondrial precursor; CGI22; MRPL14; L2mt; MRP-L2; CGI-22; MRP-L14