mitogen-activated protein kinase kinase 3

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MAP2K3

Official Full Name

mitogen-activated protein kinase kinase 3

Organism

Homo sapiens

GeneID

5606

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Synonyms

MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2;

Cat.No.	Product Name	Price
CSC-DC009160	Panoply™ Human MAP2K3 Knockdown Stable Cell Line	Inquiry
CSC-SC009160	Panoply™ Human MAP2K3 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
CSC-DC009160	Panoply™ Human MAP2K3 Knockdown Stable Cell Line	Inquiry
CSC-SC009160	Panoply™ Human MAP2K3 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
CSC-DC009160	Panoply™ Human MAP2K3 Knockdown Stable Cell Line	Inquiry
CSC-SC009160	Panoply™ Human MAP2K3 Over-expressing Stable Cell Line	Inquiry

Cat.No.	Product Name	Price
CSC-DC009160	Panoply™ Human MAP2K3 Knockdown Stable Cell Line	Inquiry
CSC-SC009160	Panoply™ Human MAP2K3 Over-expressing Stable Cell Line	Inquiry

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