Solution for Genome Editing in Rat    

Compared to mice, rats are closer to humans in terms of physiological characteristics, morphology and genetics, while their larger body and organ sizes facilitate multiple sampling and manipulation of in vivo electrophysiology, neurosurgery and neuroimaging procedures. Therefore, rats are more suitable for research in toxicology, endocrinology, oncology, neurology, cardiovascular and other fields.

Many genetically engineered rats have a wide range of applications, including gene function studies, disease modeling, and the development of new therapies. Currently, knockout and knock-in rats can be generated simply and rapidly using genome editing techniques in combination with zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN), or CRISPR/Cas9.

Fig. 1 Rat research model generation by CRISPR-Cas9 and applications. (Chenouard V, et al., 2021)

Solution

CRISPR/Cas9 Platform^CB can provide you with a variety of gene editing rat solutions such as gene knockout, point mutation and knock-in, and also provide you with a variety of strains to choose from such as SD, Wistar, Long Evans, F344, Brown Norway rats, etc. We are committed to building better rat models for you. We continuously optimize all aspects of the production gene editing process and are committed to providing comprehensive solutions for rat models, from gene editing models, surgical disease models, and breeding services to phenotypic analysis. Some examples of available genetic modifications in rats include, but are not limited to

• Constitutive and conditional knockouts
• Small fragment insertions, point mutations
• Large fragment knock-in
• Gene marker/reporter gene insertion
• Gene replacement
• Gene fusions/translocations
• Gene overexpression, induced expression, promoter modifications
• Gene editing/correction to mimic human disease

We can provide you with gene editing rat models for the following popular research areas such as psychiatric diseases, neurological diseases, cardiovascular diseases, and tumors:

• CRISPR Rat for Neurological Research
• CRISPR Rat for Behavioral Research
• CRISPR Rat for Toxicological Research
• CRISPR Rat for Immunology Research
• CRISPR Rat for Pharmacokinetic Research
• CRISPR Rat for Cardiology Research

Note: The rat models we offer are not limited to use for research in the above areas. Tell us your needs and we can customize a gene editing rat model exclusively for your research purposes.

Related Services

• Knockout Rat Model Service
• Knock-in Rats Model
• Point Mutation Rat Model Service

Related Products

• CRISPR/Cas9 Kits
• Cas9 Protein
• Cas9 mRNA
• Cas9 Related Plasmids
• Pre-made Cas9 Virus Particles

Advantages of Our Service

• Mature gene editing technology platform: rich experience in rat model construction, mature and stable technology, ensuring the stability of data between multiple batches of each model.
• Intelligent best target identification tool: artificial intelligence-based target analysis tool can intelligently identify the best target gene loci to reduce the risk of off-target.
• One-stop model animal technology service platform: covering model customization, breeding and phenotype analysis.
• Personalized technical support: our professional research team can develop a reasonable experimental plan according to your needs, and provide timely project reporting and after-sales service.

CRISPR/Cas9 Platform^CB can provide not only solutions for gene editing in rats, but also standardized phenotyping services covering cardiovascular, tumor, immune, metabolic, and neurological fields, imaging analysis, physiological and biochemical analysis, pathology analysis, gene and protein expression analysis, metabolic analysis, and cell function assays. We are committed to truly providing our clients with a complete and systematic service platform to accelerate your research process or drug development process.