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Due to its simplicity, ease of operation features, CRISPR technology has quickly become one of the most popular gene editing technologies. CRISPR relies solely on two components: molecular scissors, CRISPR-related (Cas) nucleases, and GPS, RNA (gRNA) that directs them to the appropriate sites. Cas9 is targeted to specific sites on the DNA via gRNA, which binds to a 20 base sequence in the genome adjacent to the short protospacer adjacent motif (PAM) sequence, resulting in targeted double-strand breaks (DSBs). DNA cleavage can be repaired by non-homologous end joining at the ends or by a homologous DNA-directed repair, which leads to alterations (deletions, insertions or mutations) at the target locus of a particular organism resulting in altered gene function.
The development and deployment of CRISPR technology are rapidly evolving biomedical research. Cas9-mediated genome editing has accelerated the generation of transgenic models, expanded biological research outside of traditional, genetically manageable animal model organisms (like cell models with the genetic changes arising in cancer or in genetically inherited diseases). The efficiency of Cas9 for genome editing allows for the ability to alter many targets in parallel, allowing unbiased genome-wide functional screening to identify genes that play an important role in the phenotype of interest. In addition, CRISPR/Cas9 as a treatment for genetic diseases and as a modification method of CAR T cells in cancer targeted therapy is particularly worthy of attention and expectation in the future.
As a leading genome editing Biotechnology Company, Creative Biogene CRISPR/Cas9 platformCB is committed to providing customers with a range of professional CRISPR/Cas9 services, products, and solutions. We have extensive experimental experience in CRISPR gene editing models generation, which has been fully recognized by our customers. According to your project needs, we offer the most comprehensive, cost-effective, and best-quality CRISPR/Cas9 gene editing solutions for basic research and pre-clinical research to ensure your genetic editing projects go smoothly. We guarantee to win your satisfaction in a professional way.
The CRISPR/Cas9 platformCB provides various genomic editing solutions, including but not limited to: