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CRISPR Rat for Cardiology Research 
Cardiovascular disease remains a major health problem of increasing prevalence, and the challenge remains to gain greater insight into the mechanisms behind the development of common and uncommon causes of cardiovascular mortality and morbidity. However, isolation and culture of primary human myocytes for cardiovascular research is extremely difficult.
The rat has become an important model for a range of CVD models due to its larger size, ability to perform catheterization, lower heart frequency compared to mice, and historical use in Cardiovascular disease (CVD). CRISPR/Cas9 technology has been used to generate genetic disease (e.g., severe cardiomyopathy) in a shorter time frame than traditional homologous recombination techniques. For example, severe cardiomyopathy) in rat models. In addition, CRISPR/Cas9 can now be injected into rat cell embryos for the study of cardiovascular disease. In this case, CRISPR/Cas9 technology provides a straightforward mechanism to elucidate abnormal behavior in rats by allowing reversal of causal mutations.
Fig. 1 Loss of Arhgef11 in the Dahl salt-sensitive rat protects against hypertension-Induced renal injury. (Johnson AC, et al., 2020)
Solution
CRISPR/Cas9 PlatformCB is dedicated to providing extremely valuable models for the genetics of cardiovascular disease. We manufacture gene-edited rats for cardiology research by CRISPR technology. These rats can be modified to your needs to have specific mutation models that can be used to study the effects of genetic modifications on cardiovascular disease, including systemic and pulmonary hypertension, cardiac hypertrophy and failure, myocardial infarction, coronary atherosclerotic heart disease, and stroke.
Advantages of Our CRISPR Rats
The advantages of using our RISPR rats include improved accuracy and precision in genetic engineering, faster and more efficient gene editing, and the ability to create more complex genetic modifications. In addition, our CRISPR rats are more cost-effective than traditional genetic engineering methods, and they can be used to create gene editing animals with specific characteristics. Our CRISPR rats have the following advantages:
- Highly mimics human cardiovascular disease, especially for hypertension-related studies
- Allows study of chronic, stable disease
- Produces predictable and manageable symptoms
- Allows measurement of relevant cardiac, biochemical and hemodynamic parameters
Workflow of Our CRISPR Rat Service
- Design a gene editing strategy that meets your research needs.
- Construct a plasmid-based gene editing vector.
- Inject the gene editing vector into the primary nucleus of fertilized eggs.
- Gene editing rat screening
What Can We Help You in Cardiology Research?
- Discovery of genes associated with hypertension and cardiac hypertrophy
- Studying the pathogenesis and pathological features of cardiovascular diseases
- Studying the mechanism of renin and angiotensin II-induced end-organ damage
- Analyzing the pathogenesis of end-organ injury
- Screening human renin inhibitors and developing novel antihypertensive drugs
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Reference:
- Johnson AC, et al. Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury. Hypertension. 2020, 75(4):1012-1024.