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CRISPR activation (CRISPRa) is a CRISPR tool that provides a powerful way to activate genes on a large scale in a focused manner. CRISPRa takes full advantage of a modified version of dCas9, a Cas9 mutation that does not have endonuclease activity, and fused with transcriptional activators. The screening of CRISPR-based transcriptional activation has been used to research mechanisms of human diseases, screen drug targets, and establish causal relationships between gene expression and cell fate determination. In addition, CRISPR-based gene activation is expected to be used to target endogenous gene regulatory elements to increase the expression level of normal gene copies to correct diseases caused by haploid function.
For this application, CRISPR/Cas9 PlatformCB provides customized CRISPRa sgRNA vectors construction services, including sgRNA design and viral vector packaging, which can be applied to both easy-to-transfect cells and hard-to-transfect cells. Just send us the gene ID you are interested in, we will design, clone and provide this powerful technology for you. Our custom CRISPRa sgRNA can be purchased separately or as a pre-packaged virus.
Suhyung Cho. 2018
➢ Delivery vectors and project report - Unique technology platform guarantees shorter turnaround time and lower price.
|Service||Mechanisms||Florescent tag||Resistance gene|
|Custom CRISPRa sgRNA vector||dCas9-VPR system||Available||Available|
Vectors carry fluorescent tags (GFP/mCherry, etc.), which can be used to detect the expression, and resistance gene (puromycin/neomycin) used to screen stable expression cells.
As one of the leading biotechnology companies, CRISPR/Cas9 PlatformCB has experienced experts in gene editing. We provide custom CRISPR activation sgRNA vectors construction services to meet your special needs. We are committed to providing customers with efficient solution and high-quality service to meet your specific needs. If you have any questions, please feel free to contact us. We look forward to working with you in the future.