Knockout Mouse

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Knockout Mouse    

CRISPR/Cas9 genome editing technology has revolutionized the way to create animal disease models. Scientists have used this technique numerous times to study the effects of certain genes on the mouse genome. And knockout mice provide impressive insights into the internal workings of the human genome because of the similarity between mouse and human and the effectiveness of CRISPR technology. It has many advantages:

  • Significantly reduced timelines compared to traditional gene targeting methods.
  • Effectively relocate existing animal models and repositories, potentially reducing animal usage.
  • Generate custom gene knockouts and point mutations that dramatically reduce costs.

CRISPR/Cas9 PlatformCB is a global leading biotechnology company specializing in gene editing and has extensive experience and expertise in embryology (e.g. cryopreservation, microinjection), genetic testing and breeding. Using the latest CRISPR/Cas9 gene editing technology, our scientists have successfully achieved highly efficient CRISPR/Cas9 gene editing (>98%) in a variety of animals (including mouse, rat, rabbit, zebrafish, drosophila, etc.). Based on our platform, we are able to provide you with accurate gene knockout mouse models. All mice have been verified at genomic levels by PCR and sequencing using PCR primers strategically designed around the target site or inserted fragments.

Applications

  • Study the functions of genes/proteins
  • Human disease models
  • Verify drug goals and specificities
  • Genomic verification of antibodies
  • Immunology research and drug discovery
  • Preclinical safety and toxicity studies

In addition, if you can't find the gene you're interested in, or you need another animals, or you need gene knockin/point mutation animals, check out CRISPR/Cas9 animal services. There is no doubt that CRISPR/Cas9 PlatformCB will be your best partner to support your research.

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