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As one of leading providers in genome editing field, Creative Biogene CRISPR/Cas9 PlatformCB provides comprehensive CRISPR library screening services. Our service covers from screen design and cell line selection to bioinformatics analysis of screen results. With experienced scientists, we have established three screening platforms, CRISPR knockout screening, CRISPRa and CRISPRi screening. To meet different needs, we have developed multiple assays to assess gene function. Our screening service can significantly assist customers in drug development by offering high-quality and high-confidence results.
Fig 1. Work Flow of CRISPR Library Screening
CRISPR/Cas9 PlatformCB offers one-stop screening services for customers, including CRISPR knockout screening, CRISPRi screening and CRISPRa screening. Custom screening service is welcome as well. We are aiming to serve customer with the best services.
CRISPR Knockout Screening
CRISRP knockout screening is a useful approach to identify genes essential for different biological processes. It helps to uncover new roles of known genes. Combining with different compounds, this screening is efficient to figure out potential targets for new drug.
CRISPR interference is developed on CRISPR/Cas9 technology. A repressor is linked to inactive Cas9 protein resulting in the repression of specific target gene. CRISPRi screening is used to study gene function by downregulating its expression and function other than completely knockout. This screening is ideal method to evaluate the function of genes that induce lethal when knockout.
CRISPR activation is a method that amplifies gene expression by fusing an activator to Cas9 protein. CRISPR screening provides an approach to study gain of gene function and validates loss-of-function effects from a reverse perspective. This screening helps to study the functions of genes that express low in nature condition.
CRISPR/Cas9 PlatformCB offers a series of CRISPR screening services for customers. CRISPR library screening service is applied for:
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