Solution for Genome Editing in Rabbit    

Rabbits are closer to humans than rodents in terms of anatomy, physiology, and genetics. This makes them a better model for studying human diseases and testing potential treatments. Currently, rabbits are widely used as models for various human diseases, such as cardiovascular disease, diabetes, and cancer. Gene editing techniques can be used to introduce specific mutations in rabbits that mimic these human diseases, which could help researchers study the mechanisms of disease and develop potential treatments.

Fig. 1 Illustration of GE rabbit production. (Xu J, et al., 2021)

Solution

Creative Biogene uses gene editing technologies such as CRISPR/Cas9 to efficiently and accurately introduce gene mutations in rabbits to bridge the gap between basic research and clinical applications. Our technology allows for faster and more accurate creation of disease-specific animal models than traditional breeding methods. Our rabbit models have been used for preclinical testing of a variety of therapies, including cardiovascular and oncology treatments, making them useful models for translational research. We can provide the following CRISPR rabbit models for human disease research, including but not limited to

• CRISPR Rabbit for Cardiovascular Disease Research
• CRISPR Rabbit for Infectious Disease Research
• CRISPR Rabbits for Cystic Fibrosis Research
• CRISPR Rabbits for Ocular Disease Research
• CRISPR Rabbits for Muscular Dystrophy Research
• CRISPR Rabbits for Nervous System Diseases Research

Our Process for Developing CRISPR Rabbits

• Design of guide RNAs
• Microinjection
• Embryo implantation
• Genotyping
• Reproduction
• Characterization

Why Choose Us?

• Disease modeling: Our CRISPR rabbits can be used to precisely model human diseases, which can help develop treatments for human diseases.
• Precise gene editing: Our CRISPR-Cas9 gene editing technology allows for precise modification of specific genes, enabling you to study the specific effects of gene mutations on disease progression.
• Accelerated research: Our development of CRISPR rabbit models can speed up the research process by providing animal models that more closely resemble human disease than traditional animal models.
• Improve reproducibility: Our CRISPR-Cas9 gene editing technology can produce rabbits that are genetically identical, improving the reproducibility of studies.
• Reduced cost: Using our CRISPR-Cas9 gene editing technology can reduce the cost of developing transgenic rabbit models compared to traditional methods.

Related Services

• Custom Rabbit Model

Related Products

• CRISPR/Cas9 Kits
• Cas9 Protein
• Cas9 mRNA
• Cas9 Related Plasmids
• Pre-made Cas9 Virus Particles

CRISPR/Cas9 Platform^CB has been working to develop rabbits carrying disease-causing mutations found in human patients as a model for more accurate reproduction of human disease. Our CRISPR rabbit models offer definite advantages in terms of precise gene editing, accelerated research, improved reproducibility, and cost-effectiveness. Our models promise to greatly facilitate your basic and translational research. If you are interested in our services, please feel free to contact us.