Preclinical Research

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Preclinical Research    

The rapidly evolving CRISPR-Cas9-mediated suite of gene editing technologies is generating tremendous results in modern life sciences and is an easy-to-access, programmable and accurate gene editing tool for efficient, universal transcriptional regulation and visualization genetic editing. Manipulating genes and gene expression through genome editing allow us to understand the causes of genetic dysfunction in disease and to provide guidance for developing treatments to address these deficiencies. There is no doubt that CRISPR-Cas9 is a promising approach to optimizing and innovating human disease treatment strategies.

As we know, the application of CRISPR/Cas9 makes biomedical development faster than ever. The rapid development of the versatility of this gRNA-directed genome editing system has opened up many methods for manipulating gene expression, providing new technical support for gene therapy and possibly bringing better clinical results. In 2016, the first application and clinical treatment of CRISPR fully demonstrated the feasibility of CRISPR/Cas9 for the treatment of human diseases. Now, scientists have applied CRISPR/Cas technology to drug development, target site screening, preclinical research, and clinical research in many diseases, including human genetic diseases, neurodegenerative diseases, and cancer (Figure 1).

 Applications of CRISPR/Cas9 technology in hematology research and human therapyFigure 1: Applications of CRISPR/Cas9 technology in hematology research and human therapy (Elisa González-Romero. 2019)

CRISPR/Cas9 PlatformCB is a leading genetic editing biotechnology company with an advanced national experimental platform, a team of professional scientists, extensive experience in editing CRISPR genes and the ability to handle a variety of issues. We are committed to solving technical application problems and providing the most professional and comprehensive genetic editing technology solutions for our clients. To support your projects, we offer custom CRISPR/Cas9 gene-editing services, including the design and synthesis of gRNAs for specific loci, custom human disease models (animal models and cell line models), and we also provide high-quality products, including CRISPR/Cas9 related kits, Cas9 enzyme. If you have any questions, please feel free to contact us.

References:

  1. Tianzuo Zhanab. et al. CRISPR/Cas9 for cancer research and therapy. Seminars in Cancer Biology. 2019; 55:106-119.
  2. Hasan Mollanoori and Shahram Teimourian. Therapeutic applications of CRISPR/Cas9 system in gene therapy. Biotechnology Letters. 2018; 40(6): 907–914.
  3. Jun Wan Shin and Jong-Min Lee. The prospects of CRISPR-based genome engineering in the treatment of neurodegenerative disorders. Ther Adv Neurol Disord. 2018; 11:1756285617741837.
  4. Liting You. et al. Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research. Molecular Therapy. Methods & Clinical Development. 2019; 13:359-370.
  5. Elisa González-Romero. et al CRISPR To Fix Bad Blood: A New Tool In Basic And Clinical Hematology. Haematologica. 2019; 104:881-893.

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