CRISPR/Cas9-Mediated Animal Disease Models

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CRISPR/Cas9-Mediated Animal Disease Models    

CRISPR/Cas9 is the newest member of our tool for genome editing, revolutionizing the field of genomic engineering by creating targeted breaks in virtually any organism and cell type DNA, and opening the way for biomedical research and medical applications. Animal models are very valuable in biomedical research and have been widely used to play a biological role in the development of human diseases and to find their therapeutic targets. Typically, CRISPR/Cas9-mediated animal models carry mutations in endogenous genes, rather than mutant genes expressed under exogenous promoters, thus providing a better model for mimicking human disease and increasing our understanding of disease processes and their treatment. These new animal models are also very valuable for identifying therapies using drugs or chemicals.

Now, the CRISPR/Cas9 system has been used to generate many disease-based models for many important human diseases, including neurological diseases, cancer, and cardiovascular diseases, as well as other Mendelian or complex genetic human diseases, which make it possible to study the molecular mechanisms of the underlying pathogenesis, drug screening and discovery, high-throughput research, and gene therapy. The ability of CRISPR/Cas9 to directly target any of the genes in one or both alleles of the embryonic genome opens up new avenues for large animal models. In addition to genome editing in germ cells, CRISPR/Cas9 can also efficiently target genes in somatic tissues, a method that is particularly useful for studying age-related disease physics.

 The applications of animal disease modelsFigure 1: The applications of animal disease models

CRISPR/Cas9 PlatformCB, a global leading genetic editing biotechnology company, is committed to providing the most professional and comprehensive genetic editing technology solutions for our clients working on the editing of CRISPR/Cas9 genes. To support your projects, we offer custom CRISPR/Cas9 gene editing animal model services from the strategy design to F1 animals. Typically, we develop CRISPR-mediated animals in mice, but we can use other animal strains according to your requirements. In addition, we will provide you with a final report, which details each step, including target vector design, construction and validation, transfection conditions, genotyping strategies and results. We also provide high-quality products, including CRISPR/Cas9 related kits, Cas9 enzyme. If you have any questions, please feel free to contact us.

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References:

  1. Lukas E. Dow. Modeling disease in vivo with CRISPR/Cas9. Trends Mol Med. 2015; 21(10):609–621.
  2. MartaMartinez-Lage. et al. CRISPR/Cas9 Technology: Applications and Human Disease Modeling. CRISPR in Animals and Animal Models. Progress in Molecular Biology and Translational Science. 2017; 152:23-48.
  3. Weili Yang. et al. CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases. Frontiers in Molecular Neuroscience. 2016; 9:30.
  4. Zhuchi Tu. et al. CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases. Molecular Neurodegeneration. 2015; 10:35.

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