LBR Knockout Cell Line-293T

Cat.No.
CSC-RT0159
Description
293T-LBR (-/-) is a stable cell line with a homozygous knockout of human LBR
Host Cell
293T
Species
Human
Background
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

For research use only. Not intended for any clinical use.
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